| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HECH; HP1-GAMMA; HP1Hs-gamma; CBX3 |
| Entrez GeneID | 12417 |
| WB Predicted band size | Calculated MW: 21 kDa; Observed MW: 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of mouse HP1 gamma |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3-4条关于CACNG3抗体的参考文献示例(内容为虚构，仅作格式参考)：
---
1. **标题**: "Characterization of CACNG3-Specific Antibodies for Neuronal Calcium Channel Studies"
**作者**: Burgess DL, et al.
**摘要**: 本研究开发了针对CACNG3蛋白的多克隆抗体，验证了其在Western blot和小鼠脑组织免疫荧光中的特异性，证实CACNG3在海马体和皮层神经元中高表达。
2. **标题**: "Altered CACNG3 Expression in Autism Spectrum Disorder: An Immunohistochemical Analysis"
**作者**: Smith JR, Patel K.
**摘要**: 使用CACNG3抗体对自闭症患者脑组织进行染色，发现其蛋白表达水平显著降低，提示CACNG3可能在突触可塑性异常中起作用。
3. **标题**: "CACNG3 Knockout Mouse Model Reveals Role in Seizure Susceptibility"
**作者**: Wang L, et al.
**摘要**: 通过CACNG3抗体验证基因敲除小鼠的蛋白缺失，发现CACNG3缺失导致钙通道功能异常，增加癫痫易感性。
4. **标题**: "Commercial CACNG3 Antibody Validation Challenges and Solutions"
**作者**: Gonzalez M, et al.
**摘要**: 评估了市售CACNG3抗体的交叉反应性，提出基于siRNA敲降的验证方案，强调其在神经退行性疾病研究中的可靠性问题。
---
(注：以上文献为示例，实际引用请查询PubMed等数据库获取真实研究。)
The CACNG3 antibody targets the CACNG3 protein, a member of the voltage-dependent calcium channel gamma subunit family. These subunits regulate the trafficking and functional properties of calcium channels, particularly in neuronal tissues. CACNG3. encoded by the *CACNG3* gene, is primarily expressed in the central nervous system and interacts with AMPA-type glutamate receptors, influencing synaptic plasticity and neurotransmission. Structurally, it contains four transmembrane domains and modulates ion channel activity by altering membrane localization or gating kinetics.
Research on CACNG3 has linked it to neurological and psychiatric disorders, including epilepsy, schizophrenia, and bipolar disorder. Genetic studies suggest polymorphisms in *CACNG3* may affect disease susceptibility, though mechanisms remain under investigation. The CACNG3 antibody is a critical tool for detecting protein expression, studying its interaction partners, and elucidating its role in neuronal signaling pathways. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map protein distribution in brain tissues or cultured cells. Commercially available antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Recent studies also explore its potential involvement in neurodevelopmental disorders, making this antibody valuable for both basic research and clinical investigations into calcium channel-related pathologies.
×
