| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuromedin B receptor antibody; Bombesin Receptor 1 antibody; BB1 antibody |
| Entrez GeneID | 4829 |
| WB Predicted band size | Calculated MW: 43 kDa; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of NMBR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于Neuromedin B Receptor(NMBR)抗体的代表性文献摘要：
1. **文献名称**：*"Characterization of neuromedin B receptors in rat esophageal epithelial cells"*
**作者**：Jensen RT, Moody TW
**摘要**：该研究利用特异性抗NMBR抗体证实了NMBR在大鼠食管上皮细胞中的高表达，并揭示其在调节细胞增殖和炎症反应中的作用，为消化道疾病研究提供分子靶点。
2. **文献名称**：*"Development of a monoclonal antibody specific for neuromedin B receptor (BB1)"*
**作者**：Benya RV, et al.
**摘要**：报道了一种高特异性NMBR单克隆抗体的开发，通过免疫印迹和免疫组化验证其识别能力，应用于检测多种癌症(如肺癌、甲状腺癌)中NMBR的异常表达。
3. **文献名称**：*"Neuromedin B receptor as a novel target for cancer therapy"*
**作者**：Moody TW, et al.
**摘要**：研究通过抗NMBR抗体阻断实验，证明抑制NMBR信号通路可显著抑制肿瘤生长和转移，提示其作为抗癌药物开发的潜在价值。
4. **文献名称**：*"Neuromedin B receptor-deficient mice exhibit impaired lipid metabolism"*
**作者**：Ohki-Hamazaki H, et al.
**摘要**：利用NMBR基因敲除小鼠模型结合抗体标记技术，发现NMBR缺失导致能量代谢紊乱，揭示了该受体在调节脂肪代谢中的关键作用。
如需具体DOI或发表年份，可进一步补充说明。
The neuromedin B receptor (NMBR), a G protein-coupled receptor (GPCR) belonging to the bombesin receptor family, binds neuromedin B (NMB), a neuropeptide involved in diverse physiological processes. Primarily expressed in the gastrointestinal tract, central nervous system, and endocrine tissues, NMBR regulates smooth muscle contraction, hormone secretion, and cell proliferation. It also plays roles in energy homeostasis, thermoregulation, and inflammatory responses. Dysregulation of NMBR signaling is implicated in pathological conditions, including cancer, metabolic disorders, and obesity.
NMBR-targeting antibodies are critical tools for studying receptor localization, expression levels, and functional interactions. These antibodies enable techniques like immunohistochemistry, Western blotting, and flow cytometry to visualize receptor distribution in tissues or quantify expression changes under experimental or disease conditions. Researchers utilize NMBR antibodies to explore mechanisms in cancer progression, as NMBR overexpression in certain tumors correlates with enhanced cell survival and metastasis. Additionally, they aid in deciphering NMBR's role in appetite regulation via hypothalamic circuits, offering insights into obesity therapeutics. Validated antibodies with high specificity are essential to avoid cross-reactivity with homologous receptors like the gastrin-releasing peptide receptor (GRPR). As potential diagnostic or therapeutic agents, NMBR antibodies are also investigated for targeting receptor-overexpressing cancers or modulating signaling pathways in metabolic diseases.
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