| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | PKNOX2; PREP2; Homeobox protein PKNOX2; Homeobox protein PREP-2; PBX/knotted homeobox 2 |
| Entrez GeneID | 63876 |
| WB Predicted band size | Calculated MW: 52 kDa; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human PREP-2. at AA rangle: 310-390 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于PKNOX2抗体的3篇参考文献示例(内容为模拟生成，仅供参考)：
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1. **文献名称**：*PKNOX2 regulates cortical neuronal migration through transcriptional control*
**作者**：Smith, J. et al. (2020)
**摘要**：本研究利用特异性PKNOX2抗体，通过免疫组化及染色质免疫沉淀(ChIP)技术，揭示了PKNOX2蛋白在小鼠胚胎皮层发育中的表达模式。结果发现PKNOX2通过调控下游神经元迁移相关基因(如Reelin)的转录，影响皮层神经元的层状排列，为神经发育异常疾病提供了潜在机制。
2. **文献名称**：*A novel monoclonal antibody for PKNOX2 validates its role in prostate cancer progression*
**作者**：Li, W. et al. (2018)
**摘要**：研究团队开发了一种高特异性抗人PKNOX2单克隆抗体，并通过Western blot和免疫荧光验证了其在组织样本中的可靠性。研究发现，PKNOX2在前列腺癌中表达显著下调，且其缺失与肿瘤侵袭性增强相关，提示其可能作为癌症预后标志物。
3. **文献名称**：*PKNOX2 antibody-based profiling reveals synaptic dysfunction in autism models*
**作者**：Chen, Y. et al. (2021)
**摘要**：通过PKNOX2抗体对自闭症模型小鼠脑组织进行免疫染色，发现PKNOX2在海马区突触后密度蛋白(如PSD-95)的定位异常，进一步RNA干扰实验证实PKNOX2缺失导致突触可塑性受损，提示其在神经精神疾病中的调控作用。
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**注**：以上文献为示例，实际引用需查询真实数据库(如PubMed、Web of Science)。若需准确信息，建议使用关键词“PKNOX2 antibody”或“PKNOX2 function”进行检索。
**Background of PKNOX2 Antibody**
PKNOX2 (PBX/Knotted 1 Homeobox 2) is a member of the PRE/KNOX family of transcription factors, which play roles in regulating gene expression during development and cellular differentiation. It shares structural homology with PBX proteins, characterized by a conserved homeodomain involved in DNA binding and protein-protein interactions. PKNOX2 is implicated in diverse biological processes, including embryonic development, cell fate determination, and organogenesis, often acting in partnership with other transcription factors (e.g., PBX1/2/3) to modulate target gene activity.
The PKNOX2 antibody is a critical tool for studying the protein's expression, localization, and function. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect PKNOX2 in tissues or cell lines. Research suggests PKNOX2 may contribute to neurodevelopment, hematopoiesis, and cancer progression, with altered expression observed in certain malignancies (e.g., gliomas, leukemias). However, its precise mechanisms remain under investigation, partly due to functional redundancy within the PRE/KNOX family.
Validating PKNOX2 antibody specificity is essential, as cross-reactivity with related family members (e.g., PKNOX1) can occur. Many commercial antibodies are developed using immunogenic peptides from conserved or unique regions of PKNOX2. often verified via knockout controls. Ongoing studies aim to clarify PKNOX2's role in disease pathways and its potential as a therapeutic target.
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