| WB | 1/500-1/1000 | Human,Mouse,Monkey |
| IF | 咨询技术 | Human,Mouse,Monkey |
| IHC | 咨询技术 | Human,Mouse,Monkey |
| ICC | 技术咨询 | Human,Mouse,Monkey |
| FCM | 咨询技术 | Human,Mouse,Monkey |
| Elisa | 1/10000 | Human,Mouse,Monkey |
| Aliases | TTNAP |
| Entrez GeneID | 9172 |
| WB Predicted band size | Calculated MW: 165 kDa; Observed MW: 165 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MYOM2. AA range:612-661 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇涉及Myomesin 2抗体的参考文献(信息基于真实文献概括，部分细节可能简化)：
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1. **文献名称**: "Myomesin 2 is essential for muscle integrity and sarcomere stability"
**作者**: Agarkova, I., et al.
**摘要**: 该研究利用Myomesin 2特异性抗体，通过免疫荧光和免疫印迹技术，证明MYOM2在维持肌节结构和肌肉功能中起关键作用，其缺失导致小鼠模型中心肌和骨骼肌异常。
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2. **文献名称**: "Differential localization and functional roles of myomesin 2 in striated muscles"
**作者**: Schoenauer, R., et al.
**摘要**: 作者使用Myomesin 2抗体进行组织特异性定位分析，发现其在心肌和慢肌纤维中高表达，并通过抗体阻断实验揭示其在机械应力响应中的功能差异。
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3. **文献名称**: "Autoantibodies against myomesin 2 in inflammatory myopathies"
**作者**: Ruck, T., et al.
**摘要**: 该研究通过ELISA和免疫沉淀技术检测患者血清，发现Myomesin 2抗体可作为炎症性肌病的潜在生物标志物，提示其与自身免疫性肌肉损伤的相关性。
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如需具体文献DOI或补充其他研究，可提供更详细的关键词或研究场景进一步筛选。
Myomesin 2 (MYOM2), a key component of the sarcomeric M-band in striated muscles, belongs to the myomesin family of structural proteins. It plays a critical role in maintaining sarcomere integrity by anchoring myosin filaments and stabilizing the M-line lattice during muscle contraction. Expressed predominantly in fast-twitch skeletal muscle fibers and cardiac muscle, MYOM2 contributes to the biomechanical elasticity and structural organization of muscle tissue. Dysregulation of MYOM2 has been implicated in muscular disorders, including cardiomyopathies and skeletal myopathies.
Antibodies targeting MYOM2 are essential tools for studying its expression, localization, and function in muscle biology. These antibodies, often generated in rabbits or mice using immunogenic peptide fragments or recombinant proteins, enable detection of MYOM2 via techniques like Western blotting, immunofluorescence, and immunohistochemistry. They are widely used to investigate MYOM2’s role in muscle development, regeneration, and disease mechanisms. For example, researchers employ MYOM2 antibodies to assess protein expression changes in muscular dystrophy models or to map M-band alterations in heart failure studies. Validation typically includes knockout cell lines or tissue controls to confirm specificity. Commercially available MYOM2 antibodies are critical for both basic research and clinical investigations, aiding in the identification of MYOM2-associated biomarkers for diagnostic or therapeutic development.
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