| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MKNK2; GPRK7; MNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2 |
| Entrez GeneID | 2872 |
| WB Predicted band size | Calculated MW: 52 kDa; Observed MW: 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human Mnk2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MKNK2抗体的3篇示例参考文献(内容为虚构，仅供格式参考)：
1. **文献名称**：**"Development and characterization of a monoclonal antibody targeting MKNK2 for cancer immunotherapy"**
**作者**：Smith J, et al.
**摘要**：该研究报道了一种新型抗MKNK2单克隆抗体的开发，验证其在乳腺癌细胞系中通过阻断MAPK信号通路抑制肿瘤生长的作用，并证明该抗体在体内模型中增强化疗敏感性。
2. **文献名称**：**"MKNK2 antibody-based profiling reveals its role in colorectal cancer metastasis"**
**作者**：Zhang L, et al.
**摘要**：通过免疫组织化学和Western blot分析，研究发现MKNK2在结直肠癌转移组织中高表达，其抗体标记可作为预后标志物，并揭示MKNK2通过调控eIF4E磷酸化促进肿瘤侵袭。
3. **文献名称**：**"A novel phospho-specific MKNK2 antibody identifies its activation loop dynamics in neurodegenerative disease models"**
**作者**：Chen R, et al.
**摘要**：该研究开发了一种针对MKNK2磷酸化位点的特异性抗体，揭示了在阿尔茨海默病模型中MKNK2活性异常与tau蛋白过度磷酸化的关联，为靶向治疗提供新方向。
(注：以上文献为示例，实际引用需查询PubMed、Web of Science等数据库获取真实数据。)
The MKNK2 antibody is a research tool designed to detect and study the mitogen-activated protein kinase (MAPK)-interacting kinase 2 (MKNK2), a serine/threonine kinase encoded by the MKNK2 gene. MKNK2. also known as MNK2. plays a role in the MAPK signaling pathway, where it phosphorylates eukaryotic translation initiation factor 4E (eIF4E) to regulate mRNA translation in response to extracellular stimuli like stress, growth factors, or cytokines. The kinase exists in two alternatively spliced isoforms (MNK2a and MNK2b), which exhibit distinct cellular localization and functions, with MNK2a being predominantly cytoplasmic and MNK2b showing nuclear activity.
Antibodies targeting MKNK2 are utilized to investigate its expression, activation status, and interaction partners in various biological contexts. Research has linked MKNK2 to cancer progression, immune response modulation, and neurological disorders, with studies suggesting dual roles in tumorigenesis—either promoting or suppressing tumors depending on cellular context. These antibodies are critical for techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore MKNK2's involvement in translation regulation, stress adaptation, and therapeutic resistance. Current research focuses on understanding its paradoxical roles and potential as a therapeutic target, particularly in diseases associated with dysregulated protein synthesis or MAPK pathway activation.
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