| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homo sapiens interferon alpha induced transcriptional activator; ISGF 3; P113; signal transducer and activator of transcription 2 113kD; STAT113; Stat2 |
| Entrez GeneID | 6773 |
| WB Predicted band size | Calculated MW: 98 kDa; Observed MW: 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human STAT2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于STAT2抗体的3篇参考文献的简要列举(示例基于假设性文献，具体文献需根据实际数据库检索确认)：
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1. **文献名称**: *STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor*
**作者**: Schindler, C. et al.
**摘要**: 研究利用STAT2特异性抗体，揭示了在STAT1缺失情况下，STAT2通过I型干扰素受体独立介导抗登革热病毒先天免疫应答的机制，强调了STAT2在抗病毒信号中的独特作用。
2. **文献名称**: *Differential roles of STAT1 and STAT2 in regulating TLR4-mediated gene expression*
**作者**: Platanias, L.C. et al.
**摘要**: 通过STAT2抗体进行免疫沉淀和ChIP-seq分析，发现STAT2与TLR4信号通路协同调控炎症因子(如IL-6和TNF-α)的表达，揭示了其在天然免疫中的非经典功能。
3. **文献名称**: *STAT2-dependent immune responses in cancer immunotherapy*
**作者**: Stark, G.R. & Darnell, J.E.
**摘要**: 研究使用STAT2敲除小鼠及抗体阻断实验，证明STAT2通过增强CD8+ T细胞活性抑制肿瘤生长，为STAT2靶向治疗提供了实验依据。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“STAT2 antibody”或“STAT2 signaling”获取最新研究。
STAT2 (Signal Transducer and Activator of Transcription 2) is a critical transcription factor in the JAK-STAT signaling pathway, primarily activated by type I (e.g., IFN-α/β) and type III (IFN-λ) interferons (IFNs). Upon IFN binding to receptors, STAT2 is phosphorylated by receptor-associated JAK kinases, enabling its dimerization with STAT1 and interaction with IRF9 to form the IFN-stimulated gene factor 3 (ISGF3) complex. This complex translocates to the nucleus, driving the expression of interferon-stimulated genes (ISGs) that mediate antiviral defense, immune regulation, and cell proliferation.
STAT2 is unique among STAT proteins for its specialized role in IFN signaling and limited activation by other cytokines. Dysregulation of STAT2 is linked to viral susceptibility, autoimmune disorders (e.g., lupus), and cancers. For instance, STAT2 mutations can impair antiviral responses, while its hyperactivation may promote tumor survival.
STAT2 antibodies are essential tools for studying these processes. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect STAT2 expression, phosphorylation status, and interactions. Commercial antibodies target specific epitopes (e.g., N-terminal, phosphorylated Tyr690) and are validated for species reactivity (human, mouse, rat). Researchers rely on these antibodies to explore STAT2's dual roles in immune defense and disease pathogenesis, as well as its potential as a therapeutic target. Proper validation (knockout controls, peptide blocking) is crucial to ensure specificity, given structural similarities among STAT family members.
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