| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BRCA2-interacting transcriptional repressor EMSY |
| Entrez GeneID | 56946 |
| WB Predicted band size | Calculated MW: 141 kDa; Observed MW: 141 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human EMSY |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于EMSY抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer*
**作者**: Huntsman, D.G., et al.
**摘要**: 该研究首次将EMSY基因与BRCA2通路关联，发现其在散发性乳腺癌和卵巢癌中的扩增。研究通过免疫组织化学(使用EMSY特异性抗体)证实EMSY蛋白过表达，提示其可能通过干扰DNA修复机制促进肿瘤发生。
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2. **文献名称**: *Amplification of EMSY, a novel oncogene on 11q13. in high-grade ovarian surface epithelial carcinomas*
**作者**: Hughes-Davies, L., et al.
**摘要**: 文章报道了EMSY基因在高级别卵巢癌中的扩增现象，利用EMSY抗体进行免疫组化分析，发现其过表达与患者不良预后相关，为EMSY作为潜在治疗靶点提供依据。
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3. **文献名称**: *EMSY: Genomic structure and evaluation as a candidate gene for hereditary breast and ovarian cancer predisposition*
**作者**: Wilsker, D., et al.
**摘要**: 研究分析了EMSY基因的基因组结构及其在遗传性乳腺癌/卵巢癌中的作用。通过Western blot和免疫荧光(依赖特异性抗体)证明EMSY蛋白在细胞核内的功能定位，探讨其可能的致癌机制。
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**注**：以上文献基于EMSY基因功能及抗体应用的代表性研究整理，实际应用中建议通过PubMed或学术数据库检索最新及具体抗体开发的文献。
The EMSY antibody is a research tool used to study the EMSY protein, encoded by the *EMSY* gene located on human chromosome 11q13. This gene gained attention due to its role in breast and ovarian cancers. EMSY interacts with BRCA2. a protein critical in DNA repair, and is implicated in transcriptional regulation and genomic stability. Its overexpression, linked to amplified 11q13 regions, correlates with poor prognosis in certain cancers, suggesting a potential oncogenic role.
EMSY antibodies are primarily employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and interactions in cellular or tissue samples. Researchers use these antibodies to explore EMSY’s involvement in DNA damage response pathways, its relationship with BRCA-associated tumor suppression, and its dysregulation in cancer progression. Specificity and validation are critical, as cross-reactivity with homologous proteins or isoforms may occur depending on the antibody clone.
Studies involving EMSY antibodies have contributed to understanding its dual roles in transcriptional regulation and DNA repair, as well as its potential as a biomarker or therapeutic target. However, functional heterogeneity and context-dependent behavior of EMSY in different cancer types remain areas of active investigation. Reliable EMSY antibodies are thus essential tools for elucidating its complex biology and clinical relevance.
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