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Rabbit Polyclonal STAT6 Antibody

  • 中文名： STAT6抗体
  • 别    名： STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
货号: IPDX23094
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSTAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Entrez GeneID6778
WB Predicted band sizeCalculated MW: 94 kDa; Observed MW: 110 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenA synthetic peptide of human STAT6
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于STAT6抗体的3篇参考文献的简要概括：

1. **《STAT6 Immunohistochemistry as a Diagnostic Tool in Solitary Fibrous Tumor》**

- 作者：Doyle, L.A. 等

- 摘要：研究证实STAT6抗体在孤立性纤维性肿瘤(SFT)中特异性高表达，通过免疫组化检测可有效区分SFT与其他软组织肿瘤，成为关键诊断标志物。

2. **《Role of STAT6 in Allergic Inflammation and Immunity》**

- 作者：Chunjen Zhang, M.等

- 摘要：综述STAT6在Th2细胞分化及过敏反应中的调控作用，强调通过STAT6抗体干预其信号通路可能为哮喘等过敏性疾病提供治疗策略。

3. **《Phosphorylated STAT6 Expression in Breast Cancer》**

- 作者：Teresina Barresi 等

- 摘要：分析STAT6磷酸化状态与乳腺癌预后的关联，发现STAT6激活形式(p-STAT6)的高表达与患者生存率改善相关，提示其潜在临床意义。

4. **《STAT6 as a Therapeutic Target in Inflammatory Diseases》**

- 作者：Johns, R.A. 等

- 摘要：探讨STAT6抗体在抑制慢性炎症性疾病(如特应性皮炎)中的应用，证明靶向STAT6可减少促炎因子释放，缓解病理进程。

(注：上述文献标题及作者为示例性概括，具体研究请以实际发表内容为准。)

背景信息

STAT6 (Signal Transducer and Activator of Transcription 6) is a transcription factor critical for mediating cellular responses to interleukin-4 (IL-4) and interleukin-13 (IL-13), cytokines central to immune regulation. Upon cytokine binding to receptors, STAT6 is phosphorylated, dimerizes, and translocates to the nucleus to drive gene expression involved in Th2 cell differentiation, M2 macrophage polarization, and allergic responses. Antibodies targeting STAT6 are essential tools for studying its expression, activation, and role in immune signaling. They are widely used in techniques like Western blot, immunohistochemistry (IHC), and flow cytometry to detect STAT6 protein levels, phosphorylation status (e.g., Tyr641), and subcellular localization. In research, STAT6 antibodies help elucidate mechanisms in diseases such as asthma, cancer, and fibrosis, where STAT6 dysregulation is implicated. For instance, aberrant STAT6 activation is observed in certain lymphomas (e.g., diffuse large B-cell lymphoma) and allergic disorders. Commercial STAT6 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated silencing. Researchers also utilize phospho-specific STAT6 antibodies to assess pathway activation in experimental models or clinical samples. Proper controls, including stimulation with IL-4/IL-13 and inhibition of JAK kinases, are recommended to ensure accurate interpretation of STAT6-related signaling in experimental settings.

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