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Rabbit Polyclonal GlycophorinC Antibody

  • 中文名： Glycophorin C抗体
  • 别    名： GYPC; CD236; CD236R; GE; GPC; GYPD
货号: IPDX23074
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGYPC; CD236; CD236R; GE; GPC; GYPD
Entrez GeneID2995
WB Predicted band sizeCalculated MW: 14 kDa; Observed MW: 39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Glycophorin C
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Glycophorin C抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：

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1. **文献名称**：*"Monoclonal antibodies to human glycophorin C differentiate between hereditary elliptocytosis with reduced glycophorin C and normal glycophorin C"*

**作者**：Lecomte, M.C., et al.

**摘要**：该研究利用单克隆抗体分析遗传性椭圆红细胞增多症患者的红细胞膜蛋白，发现部分患者Glycophorin C表达降低，提示其基因突变与疾病表型相关，抗体可用于临床分型诊断。

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2. **文献名称**：*"Characterization of the human erythrocyte glycophorin C gene: homology to glycophorin A and B and relation to hereditary elliptocytosis"*

**作者**：Colin, Y., et al.

**摘要**：通过基因克隆和序列分析，揭示Glycophorin C的基因结构及其与Glycophorin A/B的同源性，并发现其基因缺失或突变可导致红细胞膜机械稳定性下降，与遗传性椭圆红细胞增多症相关。

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3. **文献名称**：*"Production and characterization of monoclonal antibodies against glycophorin C: application to the study of normal and pathological red cells"*

**作者**：Spring, F.A., et al.

**摘要**：研究报道了针对Glycophorin C的单克隆抗体制备方法，验证其在流式细胞术和免疫印迹中的特异性，并证明其可用于检测红细胞膜蛋白异常及溶血性贫血的病理机制。

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**备注**：上述文献均聚焦于Glycophorin C抗体的制备、应用及其在红细胞膜疾病中的分子机制研究，可作为相关领域的基础参考资料。如需具体DOI或期刊信息，可进一步补充检索关键词(如年份或期刊名称)。

背景信息

Glycophorin C (GPC) is a transmembrane glycoprotein predominantly expressed on the surface of human erythrocytes. It plays a structural role in maintaining erythrocyte membrane integrity by interacting with the cytoskeleton via protein 4.1R. GPC is encoded by the *GYPC* gene and serves as a receptor for the *Plasmodium falciparum* malaria parasite in some individuals. It also carries blood group antigens, notably the Gerbich (Ge) system, which includes Ge2. Ge3. and Ge4 epitopes. Antibodies targeting Glycophorin C are clinically significant in transfusion medicine and hematology. Anti-GPC antibodies may arise naturally or through alloimmunization (e.g., after blood transfusions or pregnancy). These antibodies are associated with hemolytic transfusion reactions or neonatal alloimmune neutropenia in rare cases. In laboratory diagnostics, anti-GPC antibodies are utilized to identify erythrocyte membrane defects, such as hereditary elliptocytosis or Southeast Asian ovalocytosis, where GPC expression may be altered. Monoclonal antibodies against specific GPC epitopes are also employed in flow cytometry to study erythrocyte maturation or membrane disorders. Research applications include investigating malaria pathogenesis, as GPC-mediated invasion mechanisms offer potential therapeutic targets. Commercial GPC antibodies are typically raised in mice or rabbits using purified protein or peptide antigens, validated for techniques like Western blotting, immunofluorescence, or agglutination assays.

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