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Rabbit Polyclonal KAT13A Antibody

  • 中文名： KAT13A抗体
  • 别    名： bHLHe74; mNRC 1; NCoA 1; RIP160; SRC 1
货号: IPDX23070
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesbHLHe74; mNRC 1; NCoA 1; RIP160; SRC 1
Entrez GeneID8648
WB Predicted band sizeCalculated MW: 157 kDa; Observed MW: 157 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human KAT13A / SRC1
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于KAT13A抗体的3篇示例文献，内容基于典型研究场景构造，供参考：

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1. **文献名称**: *KAT13A-Mediated Histone Acetylation Regulates Neural Stem Cell Differentiation*

**作者**: Lee S, et al.

**摘要**: 本研究通过KAT13A抗体进行染色质免疫沉淀(ChIP)和Western blot分析，揭示了KAT13A在神经干细胞分化过程中通过乙酰化组蛋白H3K27调控关键基因表达的机制。

2. **文献名称**: *Role of KAT13A in Cardiac Hypertrophy via Chromatin Remodeling*

**作者**: Zhang Y, et al.

**摘要**: 利用KAT13A特异性抗体进行免疫组织化学和ChIP-seq，发现KAT13A通过修饰心肌细胞染色质结构，促进病理性心脏肥厚相关通路的激活。

3. **文献名称**: *KAT13A Antibody Validation for Epigenetic Profiling in Cancer Models*

**作者**: Gupta R, et al.

**摘要**: 本研究系统验证了KAT13A抗体的特异性，并应用于多种癌症细胞系的表观遗传分析，证实其在检测KAT13A蛋白表达及定位中的可靠性。

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**备注**：KAT13A可能为虚构或非标准命名，实际研究中常对应EP300/CBP等乙酰转移酶。建议通过UniProt或GeneCards确认蛋白标准名称后，在PubMed中以“EP300 antibody”等关键词检索真实文献。

背景信息

The KAT13A antibody is a research tool designed to detect and study KAT13A, a member of the lysine acetyltransferase (KAT) family, also known as TIP60 (Tat-interactive protein 60). KAT13A/TIP60 is a critical epigenetic regulator that acetylates histones, particularly H4 and H2A, facilitating chromatin relaxation and transcriptional activation. It plays diverse roles in DNA repair, apoptosis, cell cycle regulation, and cellular differentiation by interacting with pathways like p53. MYC, and NF-κB. Dysregulation of KAT13A is implicated in cancer progression, neurodegenerative disorders, and immune responses. The KAT13A antibody, typically developed in rabbit or mouse models, enables researchers to investigate its expression, localization, and function through techniques like Western blotting, immunoprecipitation, and immunofluorescence. Its specificity and validation (e.g., knockout validation) are crucial for ensuring accurate experimental results. Studies using this antibody have advanced understanding of KAT13A's dual role as both a tumor suppressor and oncogene, depending on cellular context. Recent research also explores its potential as a therapeutic target, particularly in cancers with aberrant acetyltransferase activity.

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