关键信息
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基因名
GADD45G/DDIT2
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简介
GADD45G/DDIT2 protein is a key mediator that regulates growth and apoptosis through the MTK1/MEKK4 MAPKKK signaling pathway. Concentration-dependent homodimerization enhances its growth inhibitory activity and interaction with PCNA, suggesting a role in DNA repair. GADD45G/DDIT2 Protein, Human (His) is the recombinant human-derived GADD45G/DDIT2 protein, expressed by E. coli , with N-6*His labeled tag.
- 应用
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95257
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表达区间
M1-E159
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蛋白长度
Full Length
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GADD45G, also known as DDIT2, is a member of the Growth Arrest and DNA Damage-inducible (GADD) gene family, which plays a crucial role in cellular stress responses, including apoptosis, cell cycle regulation, and DNA repair mechanisms. The protein is induced by environmental stressors and is implicated in various biological processes, including inflammation, differentiation, and cellular responses to oxidative stress. Research into GADD45G/DDIT2 has gained momentum due to its potential involvement in tumorigenesis and its role as a modulator of signaling pathways linked to cancer. Studies have shown that GADD45G expression is often altered in various cancers, suggesting its function as a tumor suppressor. Furthermore, understanding the molecular mechanisms by which GADD45G regulates cellular responses could provide insights into novel therapeutic strategies for cancer treatment. Recombinant GADD45G protein has been produced to facilitate functional studies aimed at elucidating its role in cellular processes and its interaction with other proteins involved in stress signaling pathways. Ongoing research is focused on characterizing the protein's structure, understanding its biological functions in greater detail, and exploring its potential as a biomarker or therapeutic target in oncological applications. This research area promises to uncover new dimensions in the understanding of cancer biology and provide avenues for innovative interventions.
