| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Follicle Stimulating Hormon; Follitropin beta chain; Follitropin subunit beta; FSHB; FSHbeta |
| Entrez GeneID | 2488 |
| WB Predicted band size | Calculated MW: 15 kDa; Observed MW: 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human FSH beta （FSHB） |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FSHβ抗体的3篇示例参考文献(部分信息为示例性内容，实际文献需通过学术数据库查询验证)：
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1. **文献名称**: *Immunization against FSHβ elicits reversible contraception in male mice*
**作者**: Kumar TR, et al.
**摘要**: 研究通过在小鼠模型中注射重组FSHβ蛋白，诱导特异性抗体生成，发现其可抑制精子发生并导致雄性暂时性不育，证明了FSHβ抗体作为男性避孕策略的潜力。
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2. **文献名称**: *Monoclonal antibodies targeting FSHβ subunit: Characterization and therapeutic implications*
**作者**: Smith A, et al.
**摘要**: 描述了针对FSHβ亚基的单克隆抗体的开发与功能验证，发现其能有效阻断FSH与受体结合，并在卵巢颗粒细胞模型中抑制雌激素合成，提示其在调控生殖内分泌中的潜在应用。
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3. **文献名称**: *Anti-FSHβ antibody reduces ovarian follicle recruitment in primates*
**作者**: Wang Y, et al.
**摘要**: 在非人灵长类动物中，使用抗FSHβ抗体可显著降低早期卵泡发育，表明FSHβ特异性抗体可能用于治疗卵巢过度刺激综合征或多囊卵巢综合征相关疾病。
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4. **文献名称**: *Structural insights into FSHβ-antibody interactions by crystallography*
**作者**: Jones R, et al.
**摘要**: 通过X射线晶体学解析FSHβ与其中和抗体的复合物结构，揭示了抗体结合表位及抑制FSH活性的分子机制，为优化抗体类药物设计提供依据。
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**注意**：以上文献信息为示例，实际引用时需通过PubMed、Web of Science等平台核实具体文献标题、作者及摘要内容。
Follicle-stimulating hormone (FSH) beta antibody is a specialized tool used to detect or quantify the beta subunit of FSH, a glycoprotein hormone critical for reproductive function. FSH, produced by the anterior pituitary gland, consists of an alpha subunit (shared with other hormones like LH and TSH) and a unique beta subunit (FSHβ) that confers biological specificity. Antibodies targeting FSHβ are essential for distinguishing FSH from structurally similar hormones in research and diagnostics.
These antibodies are typically developed in animal models (e.g., rabbits, mice) using purified or recombinant FSHβ as immunogens. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes. They are widely used in immunoassays (ELISA, Western blot, immunohistochemistry) to study FSH expression, secretion, and regulation in reproductive disorders such as infertility, polycystic ovary syndrome (PCOS), or pituitary tumors.
In clinical settings, FSHβ antibodies aid in diagnosing conditions linked to abnormal FSH levels, including ovarian failure or hypogonadism. Emerging therapeutic applications explore their potential to modulate FSH activity, such as blocking FSH receptor interactions in osteoporosis or obesity-related metabolic disorders. However, cross-reactivity with homologous subunits or species-specific variations requires rigorous validation. Current research focuses on refining antibody specificity and exploring therapeutic monoclonal antibodies targeting FSHβ to address reproductive and non-reproductive diseases.
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