| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ALDH2; ALDM; Aldehyde dehydrogenase; mitochondrial; ALDH class 2; ALDH-E2; ALDHI |
| Entrez GeneID | 217 |
| WB Predicted band size | Calculated MW: 56 kDa; Observed MW: 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ALDH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于ALDH2抗体的参考文献示例(内容为模拟生成，非真实文献)：
1. **"ALDH2抗体在心肌缺血再灌注损伤中的表达及功能研究"**
*作者：Zhang L, et al. (2018)*
**摘要**：本研究通过Western blot和免疫组化技术，利用ALDH2特异性抗体检测其在心肌组织中的表达水平，发现ALDH2活性降低与氧化应激损伤显著相关，提示其作为治疗靶点的潜力。
2. **"酒精性肝病中ALDH2基因多态性及蛋白表达分析"**
*作者：Chen Y, et al. (2020)*
**摘要**：通过ALDH2单克隆抗体进行免疫荧光染色和ELISA，揭示了ALDH2 rs671突变携带者肝脏中酶活性下降，与酒精代谢障碍及肝纤维化进展密切相关。
3. **"ALDH2抗体用于阿尔茨海默病模型的神经保护机制探索"**
*作者：Wang X, et al. (2019)*
**摘要**：在转基因小鼠模型中，ALDH2抗体被用于检测脑组织中的蛋白分布，结果表明ALDH2上调可减少β-淀粉样蛋白沉积，缓解神经炎症反应。
4. **"食管癌组织中ALDH2表达与化疗耐药性的关联研究"**
*作者：Liu H, et al. (2021)*
**摘要**：采用ALDH2多克隆抗体进行免疫组化分析，发现ALDH2低表达与顺铂耐药性相关，为预测化疗疗效提供了分子标志物。
(注：以上文献信息为示例性质，实际引用时需以真实发表的论文为准。)
**Background of ALDH2 Antibodies**
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme critical for metabolizing toxic aldehydes, including acetaldehyde—a byproduct of alcohol metabolism. The *ALDH2* gene is highly polymorphic, with a common rs671 variant (Glu504Lys) prevalent in East Asian populations, leading to reduced enzymatic activity and alcohol flush reaction. ALDH2 dysfunction is linked to diseases such as cardiovascular disorders, neurodegenerative conditions, and cancers.
ALDH2 antibodies are essential tools for detecting and quantifying ALDH2 protein expression in research and diagnostics. These antibodies are typically developed using immunogens derived from conserved regions of human ALDH2 and validated for specificity via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help study tissue-specific expression patterns, assess the functional impact of genetic variants, and explore ALDH2's role in oxidative stress and cellular detoxification pathways.
High-quality ALDH2 antibodies exhibit minimal cross-reactivity with other ALDH isoforms (e.g., ALDH1A1) and are tested across species, including human, mouse, and rat. Their applications extend to clinical research, such as identifying individuals with ALDH2 deficiency or evaluating therapeutic strategies targeting aldehyde metabolism. Reliable ALDH2 antibodies are pivotal for advancing studies on alcohol-related pathologies, cancer metabolism, and precision medicine approaches.
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