| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ALDOA; ALDA; Fructose-bisphosphate aldolase A; Lung cancer antigen NY-LU-1; Muscle-type aldolase |
| Entrez GeneID | 226 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Aldolase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ALDOA抗体相关的文献示例(注意：文献信息为模拟生成，实际引用请核实原文)：
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1. **标题**：*Autoantibodies against aldolase A in patients with dermatomyositis*
**作者**：Casciola-Rosen L, et al.
**摘要**：该研究鉴定了多发性肌炎/皮肌炎患者血清中存在抗ALDOA的自身抗体，并探讨其与疾病活动性的关联。通过免疫沉淀和蛋白质印迹法证实了ALDOA作为自身抗原的病理作用。
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2. **标题**：*Aldolase A as a prognostic biomarker in hepatocellular carcinoma*
**作者**：Chang Y, et al.
**摘要**：研究通过免疫组化分析肝癌组织中ALDOA蛋白表达水平，发现其高表达与肿瘤转移和患者生存期缩短显著相关，提示ALDOA可能作为肝癌治疗的潜在靶点。
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3. **标题**：*Aldolase A promotes cell glycolysis and growth in gastric cancer via Wnt/β-catenin signaling*
**作者**：Zhang H, et al.
**摘要**：该研究利用ALDOA抗体进行Western blot和免疫荧光实验，证实ALDOA通过激活Wnt/β-catenin通路增强胃癌细胞的糖酵解能力，促进肿瘤增殖。
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如需具体文献，建议通过PubMed或Web of Science以“ALDOA antibody”为关键词检索，并筛选涉及疾病机制、诊断标志物或治疗靶点的研究。
The ALDOA antibody targets aldolase A, a glycolytic enzyme encoded by the ALDOA gene. This enzyme catalyzes the cleavage of fructose-1.6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, a critical step in glycolysis. ALDOA is highly expressed in muscle tissues, where it supports energy production, but it also plays roles in non-glycolytic processes, including cytoskeleton organization and cell motility. Dysregulation of ALDOA has been implicated in various pathologies. Overexpression is observed in cancers like lung, liver, and pancreatic carcinomas, where it may promote tumor growth and metastasis. Conversely, ALDOA deficiency is linked to rare hereditary disorders, such as glycogen storage disease XII, causing exercise intolerance and muscle weakness.
ALDOA antibodies are widely used in research to study protein expression, localization, and function in disease models. They are essential tools in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available antibodies vary in specificity, with some cross-reacting with aldolase isoforms (B and C), necessitating careful validation. Recent studies also explore ALDOA’s potential as a biomarker for cancer prognosis or therapeutic targeting. Its dual role in metabolism and cellular structure makes it a compelling subject for understanding disease mechanisms and developing targeted therapies.
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