| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NFKBIE; IKBE; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon |
| Entrez GeneID | 4794 |
| WB Predicted band size | Calculated MW: 53 kDa; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human IKB epsilon |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IKB epsilon(IKBKE)抗体的3篇参考文献概览，涵盖其功能研究和应用方向：
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1. **文献名称**: *"IKBKE is required for glioblastoma invasion via modulation of NF-κB signaling"*
**作者**: Li X. et al.
**摘要**: 该研究利用IKBKE特异性抗体，通过免疫印迹和免疫荧光技术，证实了IKBKE在胶质母细胞瘤细胞中的高表达，并揭示其通过激活NF-κB通路促进肿瘤侵袭的机制。
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2. **文献名称**: *"IKBKE negatively regulates antiviral responses by disrupting the STING-TBK1 complex"*
**作者**: Zhang Q. et al.
**摘要**: 研究通过IKBKE抗体进行免疫共沉淀实验，发现IKBKE与STING蛋白互作，抑制TBK1激酶活性，从而削弱宿主细胞的抗病毒干扰素反应，为病毒感染治疗提供新靶点。
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3. **文献名称**: *"Targeting IKBKE in HER2-positive breast cancer: Therapeutic implications of a novel oncogenic kinase"*
**作者**: Harris J.L. et al.
**摘要**: 该研究使用IKBKE抗体进行组织芯片分析，发现HER2阳性乳腺癌中IKBKE异常激活，并通过体外实验证明其抗体介导的基因沉默可显著抑制肿瘤生长，提示其作为潜在治疗靶点。
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每篇文献均通过IKBKE抗体进行蛋白定位、功能验证或病理机制研究，涉及肿瘤学、免疫调控及抗病毒领域。如需具体文献来源(期刊、年份)，可进一步补充数据库检索。
The IκB epsilon (IκBε) antibody is a key tool for studying the regulatory mechanisms of the NF-κB signaling pathway. IκBε, encoded by the *NFKBIE* gene, belongs to the inhibitor of κB (IκB) family, which includes proteins like IκBα and IκBβ. Structurally, IκBε contains characteristic ankyrin (ANK) repeat domains that enable its interaction with NF-κB dimers, sequestering them in the cytoplasm and preventing their nuclear translocation. Upon cellular stimulation (e.g., cytokines, pathogens), the IκB kinase (IKK) complex phosphorylates IκB proteins, marking them for proteasomal degradation. This releases NF-κB to activate genes involved in immune responses, inflammation, and cell survival.
Unlike IκBα, which is rapidly degraded and resynthesized, IκBε exhibits delayed degradation kinetics, suggesting a role in fine-tuning prolonged or specific NF-κB activation, particularly in immune cells. Research highlights its importance in Toll-like receptor (TLR) and cytokine receptor signaling, where it modulates inflammatory responses. Dysregulation of IκBε has been linked to autoimmune diseases, chronic inflammation, and cancers, making it a potential therapeutic target.
The IκBε antibody is widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to analyze protein expression, localization, and interactions. It aids in elucidating context-dependent NF-κB regulation and its implications in disease pathogenesis, offering insights for targeted intervention strategies.
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