| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MEN1; SCG2; Menin |
| Entrez GeneID | 4221 |
| WB Predicted band size | Calculated MW: 68 kDa; Observed MW: 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Menin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Menin抗体的模拟参考文献示例(注：文献信息为模拟生成，建议通过学术数据库核实具体内容)：
1. **文献名称**：*Menin interacts with the histone methyltransferase complex to regulate gene expression*
**作者**：Huang J, et al.
**摘要**：本研究利用Menin特异性抗体，通过免疫共沉淀技术揭示了Menin与组蛋白甲基转移酶复合物(如MLL1)的相互作用，阐明了其在表观遗传调控和肿瘤抑制中的分子机制。
2. **文献名称**：*Targeting Menin in acute leukemia through protein-protein interaction inhibition*
**作者**：Dreijerink KMA, et al.
**摘要**：通过开发Menin抗体和小分子抑制剂，研究团队验证了阻断Menin与致癌蛋白(如MLL融合蛋白)结合的策略，为白血病治疗提供了潜在靶点。
3. **文献名称**：*Tissue-specific roles of Menin in a mouse model of MEN1 syndrome*
**作者**：Matoso A, et al.
**摘要**：利用Menin抗体进行免疫组化分析，发现Men1基因敲除小鼠模型中胰腺和垂体的特异性表型变化，支持Menin在肿瘤抑制中的组织特异性功能。
4. **文献名称**：*Menin antibody-based detection in neuroendocrine tumors*
**作者**：Cao Y, et al.
**摘要**：研究开发了一种高特异性Menin抗体，用于鉴别多发性内分泌肿瘤(MEN1)患者的组织样本，证明其在临床诊断和分子分型中的应用潜力。
**建议**：可通过PubMed或Google Scholar检索关键词“Menin antibody”、“MEN1 protein detection”获取真实文献。
Menin antibodies are immunological tools designed to target the Menin protein, a product of the MEN1 gene. Menin is a scaffold protein with multifaceted roles in transcriptional regulation, genomic stability, and cell proliferation. It interacts with diverse partners, including histone modifiers (e.g., MLL complexes) and signaling pathways, influencing processes like chromatin remodeling and gene expression. Menin loss-of-function mutations cause multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant syndrome characterized by tumors in endocrine organs (e.g., parathyroid, pancreas, pituitary). Menin antibodies are critical for studying its molecular functions, detecting expression levels in tissues, and exploring its tumor-suppressive mechanisms.
Recent research highlights Menin's involvement in cancers beyond MEN1 syndrome, such as leukemia, where Menin-MLL interactions drive oncogenic gene programs. Inhibitors disrupting Menin-MLL binding are under investigation as therapies. Menin antibodies also aid in diagnosing MEN1-related tumors and understanding tissue-specific roles. Additionally, studies suggest Menin may modulate inflammatory responses and metabolic pathways, linking it to broader pathologies like diabetes or autoimmune disorders.
While Menin antibodies are primarily research tools, their applications extend to validating therapeutic targeting strategies. Challenges include elucidating context-dependent Menin interactions and reconciling its dual roles as a tumor suppressor or oncogenic collaborator in different cancers. Ongoing work aims to refine antibody specificity for diagnostic and functional studies, advancing both basic science and clinical translation.
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