| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bence Jones protein; BJP; Constant region of lambda light chains; Ig lambda chain C regions; IGLC; IGLC1; IGLC2; IGLC3; IGLC6; IGLV; Immunoglobulin lambda constant 1; Mcg marker; Paraprotein |
| Entrez GeneID | 28820/3537 |
| WB Predicted band size | Calculated MW: 25 kDa; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Lambda Light chain |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与Lambda轻链抗体相关的参考文献摘要(文献信息为模拟示例，仅供参考)：
---
1. **文献名称**：*Detection of Free Lambda Light Chains in Patients with Plasma Cell Disorders*
**作者**：A. Dispenzieri et al.
**摘要**：探讨了通过免疫固定电泳和游离轻链检测(FLC)在浆细胞疾病(如多发性骨髓瘤)中Lambda轻链的定量分析方法，强调了其在早期诊断和疗效监测中的价值。
2. **文献名称**：*Structural Insights into Lambda Light Chain Aggregation in Amyloidosis*
**作者**：M. Ramirez-Alvarado et al.
**摘要**：通过X射线晶体学解析Lambda轻链蛋白的异常聚集机制，揭示了其在AL型淀粉样变性中的致病机理，为靶向治疗提供结构基础。
3. **文献名称**：*Lambda Light Chain-Specific Antibodies for Immunohistochemical Diagnosis*
**作者**：K. Leung et al.
**摘要**：开发了一种高特异性抗人Lambda轻链单克隆抗体，验证了其在组织切片中鉴别单克隆Lambda轻链沉积病(如轻链肾病)的临床应用潜力。
---
注：以上文献为示例，实际引用需根据具体研究通过PubMed或学术数据库检索真实发表内容。
Lambda light chain antibodies are specialized reagents used to detect lambda-type light chains, a component of immunoglobulins (antibodies). In humans, antibodies consist of two heavy chains and two light chains, with light chains existing as either kappa (κ) or lambda (λ) types. Approximately 40% of antibodies in healthy individuals contain lambda chains. Lambda light chain antibodies are critical tools in research and diagnostics, particularly for identifying clonal B-cell populations.
In normal immune responses, B-cells produce a mix of κ and λ antibodies, maintaining a κ:λ ratio of about 2:1. Deviations from this ratio may indicate monoclonal proliferation, such as in multiple myeloma or lymphoproliferative disorders. Lambda-specific antibodies help distinguish between polyclonal (reactive) and monoclonal (neoplastic) conditions in tissue biopsies, flow cytometry, or serum/urine tests. They are also used to detect free light chains in conditions like light chain amyloidosis or light chain deposition disease, where misfolded lambda chains accumulate in organs.
Commercially available lambda antibodies target conserved regions of the lambda constant domain, enabling broad reactivity across species or isoform-specific detection. In research, they aid in studying B-cell development, antibody diversity, and disease mechanisms. Clinically, they support diagnosis, prognosis, and monitoring of plasma cell dyscrasias. Their specificity makes them indispensable for precise immunophenotyping and understanding pathological light chain behavior.
×
