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Rabbit Polyclonal GAD67 Antibody

  • 中文名： GAD67抗体
  • 别    名： Glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD 67; GAD1; GAD; GAD67
货号: IPDX22918
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGlutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD 67; GAD1; GAD; GAD67
Entrez GeneID2571
WB Predicted band sizeCalculated MW: 67 kDa; Observed MW: 67 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human GAD67
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于GAD67抗体的参考文献概览：

1. **《Autoantibodies against GAD67 in cerebellar ataxia》**

*作者：Tanaka et al.*

**摘要**：研究报道了GAD67自身抗体与罕见的小脑性共济失调的关联，发现患者血清中的抗体会抑制GAD67酶活性，可能导致GABA能神经传递异常，进而引发运动协调障碍。

2. **《GAD65 and GAD67 autoantibodies in type 1 diabetes》**

*作者：Pietropaolo et al.*

**摘要**：分析1型糖尿病患者中GAD67抗体的临床意义，发现其与GAD65抗体共存率高，可能作为胰岛β细胞自身免疫破坏的早期标志，且与特定HLA基因型相关。

3. **《Immunohistochemical localization of GAD67 in the rat brain》**

*作者：Esclapez et al.*

**摘要**：通过GAD67特异性抗体的免疫组化研究，详细绘制了大鼠脑内GABA能神经元的分布，证实GAD67广泛表达于抑制性神经元胞体，为神经环路研究提供关键工具。

*注：若需更多文献，建议在PubMed或Web of Science以“GAD67 antibody”或“GAD67 autoantibody”为关键词检索近年研究。*

背景信息

The GAD67 antibody is an autoantibody targeting glutamic acid decarboxylase 67 (GAD67), a key enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. GAD67. one of two GAD isoforms (GAD65 and GAD67), is predominantly expressed in GABAergic neurons and pancreatic β-cells. Autoantibodies against GAD67 are strongly associated with autoimmune neurological disorders, including stiff-person syndrome (SPS), cerebellar ataxia, and epilepsy, as well as type 1 diabetes (T1D). In SPS, these antibodies are thought to impair GABA synthesis, leading to hyperexcitability of motor neurons and characteristic muscle rigidity. While GAD65 antibodies are more commonly linked to T1D, GAD67 antibodies are occasionally detected in overlapping autoimmune conditions. Laboratory testing for GAD67 antibodies aids in diagnosing rare neurological syndromes, often requiring correlation with clinical symptoms. Research continues to explore their pathogenic role, with studies suggesting potential epitope-specific effects or synergies with other autoantibodies. Despite their diagnostic relevance, the exact mechanisms by which GAD67 antibodies contribute to disease progression remain under investigation, highlighting the complexity of autoimmune targeting in neurological and metabolic disorders.

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