| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATL1 alpha; ATL1 beta; ATL1 gamma; ATL1 delta; Bcl11b; BCL11B/TRDC fusion; CTIP2; hRIT1 alpha; hRit1; Rit1 |
| Entrez GeneID | 64919 |
| WB Predicted band size | Calculated MW: 96 kDa; Observed MW: 140 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Ctip2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Ctip2(Bcl11b)抗体的3篇代表性文献，涵盖不同研究方向：
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1. **文献名称**: *Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo*
**作者**: Arlotta P, et al.
**期刊**: *Neuron* (2004)
**摘要**: 研究利用Ctip2抗体标记小鼠胚胎皮质脊髓运动神经元，发现Ctip2是调控该类神经元分化和轴突投射的关键转录因子。基因敲除小鼠显示皮质脊髓束发育缺陷。
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2. **文献名称**: *Bcl11b is required for differentiation of thymic medullary epithelial cells*
**作者**: Avram D, et al.
**期刊**: *Journal of Immunology* (2010)
**摘要**: 通过Ctip2抗体染色和条件敲除模型，证明Bcl11b在胸腺髓质上皮细胞分化中起关键作用，影响T细胞选择与免疫耐受，为自身免疫疾病机制提供新见解。
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3. **文献名称**: *Ctip2 controls stem cell traits and cell fate decisions in the developing skin*
**作者**: Tumbar T, et al.
**期刊**: *Development* (2006)
**摘要**: 使用Ctip2抗体揭示其在表皮干细胞中的表达模式，发现Ctip2通过调控角蛋白基因(如Krt1/Krt10)参与皮肤屏障形成和毛囊分化，缺失导致表皮发育异常。
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**备注**：Ctip2抗体常用于免疫组化(IHC)、免疫荧光(IF)和染色质免疫沉淀(ChIP)实验，上述文献均涉及其在细胞命运决定中的功能研究。如需具体实验步骤或商业抗体信息，可进一步补充说明。
The CTIP2 antibody is a widely used tool in neuroscience and immunology research, targeting the COUP-TF-interacting protein 2 (CTIP2), also known as B-cell leukemia/lymphoma 11B (BCL11B). CTIP2 is a zinc-finger transcription factor critical for cortical development, neuronal differentiation, and immune cell maturation. It plays essential roles in regulating gene expression during corticogenesis, particularly in layer V subcortical projection neurons, and is involved in T-cell lineage commitment and thymocyte development.
First characterized in the early 2000s, CTIP2 antibodies were developed to study its expression patterns and functional mechanisms. These antibodies enable detection of CTIP2 protein in tissues like the brain, thymus, and skin via techniques including immunohistochemistry, Western blotting, and flow cytometry. Their specificity has made them invaluable for exploring CTIP2's dual roles in neural circuit formation and immune regulation, as well as its implications in diseases. For example, CTIP2 dysregulation is linked to intellectual disabilities, T-cell malignancies, and epithelial-to-mesenchymal transition in cancers.
Commercial CTIP2 antibodies are often raised against conserved epitopes in humans, mice, and rats, facilitating cross-species studies. Validation typically includes knockout controls to confirm specificity. Researchers rely on these antibodies to map developmental pathways, study disease mechanisms, and screen therapeutic targets, underscoring their versatility in both basic and translational research.
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