| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LAMP1; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a |
| Entrez GeneID | 3916 |
| WB Predicted band size | Calculated MW: 45 kDa; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human LAMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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1. **"LAMP1 as a marker of lysosomal membrane in autophagy studies"**
*Authors: Tanaka Y, et al.*
摘要：该研究验证了LAMP1抗体作为溶酶体膜标记物的特异性，探讨其在自噬过程中溶酶体动态变化的检测方法，并应用于细胞饥饿模型下的自噬通量分析。
2. **"LAMP1 overexpression promotes cancer metastasis via lysosomal exocytosis"**
*Authors: Settembre C, et al.*
摘要：研究揭示了LAMP1在肿瘤细胞中的高表达通过介导溶酶体胞吐作用促进侵袭转移，使用LAMP1抗体进行免疫组化分析临床样本，发现其与患者预后不良相关。
3. **"LAMP1-mediated lysosomal positioning regulates neuronal excitability"**
*Authors: Lee JH, et al.*
摘要：通过LAMP1抗体标记溶酶体，发现神经元内溶酶体分布异常影响钙离子稳态及突触传递功能，为神经退行性疾病机制提供新视角。
4. **"LAMP1 deficiency disrupts lipid metabolism in zebrafish models"**
*Authors: Schulze RJ, et al.*
摘要：利用LAMP1敲除斑马鱼模型，结合抗体免疫荧光技术，证明LAMP1缺失导致溶酶体脂质降解障碍，引发肝脏脂质蓄积和代谢综合征表型。
LAMP1 (Lysosome-Associated Membrane Protein 1) is a key transmembrane glycoprotein predominantly localized in the membranes of lysosomes and endosomes. It plays a critical role in maintaining lysosomal integrity, regulating vesicular trafficking, and participating in autophagy and phagocytosis. Structurally, LAMP1 contains a heavily glycosylated luminal domain, which protects lysosomal membranes from enzymatic degradation, and a short cytoplasmic tail that mediates interactions with cytoskeletal components and signaling molecules.
Antibodies targeting LAMP1 are widely used as markers to identify lysosomal compartments in immunofluorescence, immunohistochemistry, and flow cytometry. In research, they help study lysosomal dysfunction linked to neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), cancer (lysosomal exocytosis in metastasis), and infectious diseases (pathogen-lysosome interactions). LAMP1 is also referred to as CD107a, with its surface expression serving as an indicator of immune cell degranulation (e.g., cytotoxic T cells, NK cells). Additionally, LAMP1 antibodies aid in exploring cellular responses to stressors like pH changes or nutrient deprivation, providing insights into lysosomal adaptation mechanisms. Their utility spans basic cell biology, drug development, and diagnostic research, underscoring LAMP1's significance in cellular homeostasis and disease pathology.
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