| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TF6; HMSNP; SPG57; TRKT3 |
| Entrez GeneID | 10342 |
| WB Predicted band size | Calculated MW: 43 kDa; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TRK fused gene |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TFG抗体的3篇模拟参考文献示例(注：以下为虚构内容，建议通过学术数据库查询真实文献)：
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1. **文献名称**: "TFG Antibodies in Autoimmune Neuropathies: Clinical and Serological Correlations"
**作者**: Smith A, et al.
**摘要**: 本研究探讨了TFG抗体在慢性炎症性脱髓鞘性多神经病(CIDP)患者中的阳性率及临床意义，发现TFG抗体阳性患者更易出现感觉运动障碍，提示其可能作为亚型分层的生物标志物。
2. **文献名称**: "Paraneoplastic Neurological Syndromes Associated with TFG Autoantibodies"
**作者**: Johnson R, et al.
**摘要**: 报道了3例TFG抗体阳性的副肿瘤性神经综合征病例，患者均伴发小细胞肺癌。研究表明TFG抗体可能通过靶向神经元胞内蛋白引发免疫反应，并与肿瘤微环境存在交叉反应。
3. **文献名称**: "TFG Antibody as a Novel Biomarker in Idiopathic Small Fiber Neuropathy"
**作者**: Lee S, et al.
**摘要**: 通过队列研究发现，特发性小纤维神经病变患者中TFG抗体的检出率显著高于健康对照组，提示其可能参与痛觉传导通路的自身免疫损伤机制。
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**建议**：
如需真实文献，可通过PubMed、Google Scholar等平台以关键词“TFG antibody”、“TFG autoantibody”或“TFG protein neurology”检索，并优先选择近5年发表于《Journal of Neuroimmunology》《Neurology》等权威期刊的研究。
The TFG (TRK-fused gene) protein, encoded by the *TFG* gene on chromosome 3q12.2. is a conserved regulatory factor involved in intracellular vesicle trafficking, particularly in endoplasmic reticulum (ER)-to-Golgi transport. It contains structural motifs such as coiled-coil domains and a leucine zipper, enabling interactions with proteins like Sec16A and COPII components to modulate cargo sorting and ER export. Dysregulation of TFG is linked to pathological conditions. For instance, chromosomal rearrangements fusing *TFG* with kinases like ALK or NTRK1 drive oncogenic signaling in cancers such as ALK-positive anaplastic large cell lymphoma and papillary thyroid carcinoma. Additionally, TFG mutations (e.g., p.Pro285Leu) are associated with hereditary motor and sensory neuropathy with proximal predominance (HMSN-P), a neurodegenerative disorder characterized by protein aggregation and ER stress.
TFG antibodies are critical tools for studying these mechanisms. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TFG expression, localization, and interaction partners in disease models. Commercially available monoclonal and polyclonal antibodies target specific epitopes, aiding research on TFG’s role in secretory pathway regulation, neurodegeneration, and cancer biology. These antibodies also hold diagnostic potential, helping identify TFG-related fusion proteins or mutations in clinical samples, thereby guiding therapeutic strategies for precision medicine.
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