| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor jun-B |
| Entrez GeneID | 3726 |
| WB Predicted band size | Calculated MW: 36 kDa; Observed MW: 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human JunB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于JunB抗体的参考文献及其简要摘要：
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1. **文献名称**：*"JunB is essential for mammalian placentation"*
**作者**：Schorpp-Kistner, M. et al.
**摘要**：该研究通过基因敲除小鼠模型，发现JunB在胎盘发育中起关键作用，并利用JunB抗体证实其在滋养层细胞分化中的表达调控，提示其与胚胎存活密切相关。
2. **文献名称**：*"Regulation of JunB expression by NF-κB and JNK signaling in T lymphocytes"*
**作者**：Li, B. et al.
**摘要**：研究揭示了T细胞中JunB的转录调控机制，通过JunB抗体进行染色质免疫沉淀(ChIP)实验，证明NF-κB和JNK通路协同调控JunB表达，影响T细胞活化和炎症反应。
3. **文献名称**：*"JunB contributes to Id2 repression and the epithelial-mesenchymal transition in cancer cells"*
**作者**：Yoshida, T. et al.
**摘要**：该文献利用JunB抗体进行免疫印迹和免疫组化分析，发现JunB通过抑制Id2基因表达促进癌细胞的上皮-间质转化(EMT)，增强肿瘤侵袭性。
4. **文献名称**：*"Antibody-based detection of AP-1 family proteins in human pathologies"*
**作者**：Smith, J. & Wei, L.
**摘要**：综述了AP-1家族蛋白(包括JunB)在人类疾病中的检测方法，重点讨论了JunB抗体的特异性验证及其在癌症和自身免疫疾病组织样本中的应用实例。
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以上文献均聚焦于JunB蛋白的功能研究及抗体实验方法，涵盖发育生物学、免疫调控和癌症机制等领域。如需具体期刊信息或年份，可进一步补充关键词检索。
JunB antibody is a crucial tool in molecular biology research, targeting the JunB protein, a member of the AP-1 (Activator Protein 1) transcription factor family. JunB, encoded by the *JUNB* gene, regulates gene expression by forming dimers with other AP-1 proteins like c-Fos or other Jun family members. It plays diverse roles in cellular processes, including proliferation, differentiation, apoptosis, and immune responses. JunB is involved in pathways like MAPK/ERK and TGF-β, influencing cell cycle progression and tissue homeostasis. Dysregulation of JunB is linked to diseases such as cancer, autoimmune disorders, and developmental defects. For instance, its overexpression is observed in certain lymphomas, while reduced levels correlate with skin disorders.
JunB antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to detect JunB expression, localization, and DNA-binding activity. These antibodies aid in studying its role in tumorigenesis, inflammation, and stem cell biology. Specificity and validation (e.g., knockout controls) are critical due to structural similarities within the AP-1 family. Commercial JunB antibodies are typically monoclonal or polyclonal, with applications in both basic research and clinical diagnostics, offering insights into disease mechanisms and potential therapeutic targets.
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