| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IL-1 Receptor Antagonist Protein; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA |
| Entrez GeneID | 3557 |
| WB Predicted band size | Calculated MW: 20 kDa; Observed MW: 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human IL1RA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IL-1受体拮抗剂蛋白(IL-1Ra)抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*Interleukin-1 receptor antagonist: role in biology and therapy*
**作者**：Dinarello, C.A.
**摘要**：该综述总结了IL-1Ra的生物学功能及其在炎症性疾病中的治疗潜力，讨论了针对IL-1Ra的抗体在实验模型中如何用于研究其抑制IL-1信号通路的机制，并强调了其在类风湿性关节炎和脓毒症中的临床应用前景。
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2. **文献名称**：*Interleukin-1 receptor antagonist expression in human neutrophils*
**作者**：Malyak, M., Smith, M.F., Abel, A.A., et al.
**摘要**：研究通过单克隆抗体检测中性粒细胞中IL-1Ra的分泌，发现其在炎症反应中通过竞争性结合IL-1受体抑制炎症，为开发靶向IL-1Ra的诊断工具提供实验依据。
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3. **文献名称**：*Monoclonal antibodies directed against human interleukin-1 receptor antagonist (IL-1Ra): a tool for studying IL-1Ra in vivo*
**作者**：Gabay, C., Smith, M.F., Eidlen, D., et al.
**摘要**：研究团队开发了高特异性抗IL-1Ra单克隆抗体，用于检测动物模型中IL-1Ra的分布和功能，证实其在炎症调控中的关键作用，并为靶向IL-1通路的治疗策略提供新思路。
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**注**：若需更多文献或具体研究细节，可进一步提供方向或补充关键词(如特定疾病模型或抗体类型)。
The IL-1 Receptor Antagonist Protein (IL-1Ra) is a naturally occurring cytokine inhibitor that modulates the activity of interleukin-1 (IL-1), a key mediator of inflammation and immune responses. IL-1Ra binds competitively to IL-1 receptors (IL-1R1), blocking the pro-inflammatory effects of IL-1α and IL-1β without activating downstream signaling. This unique mechanism makes IL-1Ra a critical regulator of IL-1-driven pathologies, including autoimmune diseases, sepsis, and chronic inflammation.
Antibodies targeting IL-1Ra are valuable tools for studying its expression, localization, and functional roles. They are widely used in immunoassays (e.g., ELISA, Western blot, immunohistochemistry) to quantify IL-1Ra levels in biological samples or to inhibit its activity in experimental models. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect diverse epitopes, enhancing detection sensitivity. Some therapeutic antibodies or recombinant proteins, like anakinra (a synthetic IL-1Ra), have been developed to mimic or augment IL-1Ra’s antagonistic effects, demonstrating clinical efficacy in conditions such as rheumatoid arthritis.
Research on IL-1Ra antibodies also explores their diagnostic potential, as altered IL-1Ra levels correlate with disease severity in inflammatory disorders. Additionally, these antibodies help elucidate IL-1 signaling pathways, aiding drug development and personalized treatment strategies. However, challenges remain in optimizing antibody affinity and minimizing cross-reactivity with related IL-1 family members. Overall, IL-1Ra antibodies serve as essential reagents in both basic research and translational applications targeting IL-1-mediated diseases.
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