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Rabbit Polyclonal Cyclooxygenase1 Antibody

  • 中文名: Cyclooxygenase 1抗体
  • 别    名: PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
货号: IPDX22837
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
Entrez GeneID5742
WB Predicted band sizeCalculated MW: 69 kDa; Observed MW: 69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human COX1
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Cyclooxygenase 1(COX-1)抗体的3篇参考文献示例(内容基于公开研究整理,具体细节请核实原文):

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1. **"Immunohistochemical localization of cyclooxygenase-1 in human tissues"**

- **作者**: Smith WL, et al.

- **摘要**: 该研究通过特异性COX-1抗体,系统分析了COX-1在人类多种组织(如胃、肾、血小板)中的分布,证实其在维持基础生理功能中的广泛表达,与COX-2的诱导性表达形成对比。

2. **"Characterization of monoclonal antibodies specific for cyclooxygenase-1 (COX-1)"**

- **作者**: Chen Y, et al.

- **摘要**: 研究报道了一种高特异性COX-1单克隆抗体的开发与验证,证明其可用于免疫印迹(Western blot)和免疫沉淀,且与COX-2无交叉反应,适用于炎症和癌症模型中的靶标检测。

3. **"Differential expression of COX-1 and COX-2 in gastrointestinal mucosa"**

- **作者**: Dubois RN, et al.

- **摘要**: 利用COX-1和COX-2抗体对比分析胃肠道中两种酶的分布,发现COX-1在正常黏膜上皮细胞中持续表达,而COX-2在炎症或肿瘤组织中显著上调,提示两者病理生理功能的差异。

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如需具体文献来源,建议通过PubMed或Web of Science检索标题或作者名获取全文。

背景信息

Cyclooxygenase 1 (COX-1) is a constitutively expressed enzyme that plays a key role in prostaglandin biosynthesis, regulating physiological functions such as gastric mucosal protection, platelet aggregation, and renal blood flow. Unlike its inducible isoform COX-2. COX-1 is ubiquitously present in most tissues under normal conditions, maintaining homeostasis. Antibodies targeting COX-1 are essential tools for studying its expression, localization, and regulatory mechanisms in both healthy and diseased states.

COX-1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein levels in various cell types and tissues. They help investigate COX-1's role in pathologies, including inflammation, cardiovascular diseases, and cancer, where altered expression may correlate with disease progression or drug resistance. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin irreversibly inhibit COX-1. underscoring the need to study its activity in therapeutic contexts.

Researchers validate COX-1 antibodies using knockout models or siRNA-mediated knockdown to ensure specificity, as cross-reactivity with COX-2 can confound results. Commercial antibodies are often raised against unique peptide sequences within COX-1’s catalytic or regulatory domains. Applications extend to pharmacodynamic studies, biomarker discovery, and understanding tissue-specific responses to COX inhibitors. Despite its "housekeeping" role, COX-1 remains a dynamic research target, with antibodies serving as critical reagents to unravel its complex biology.

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