首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal VAV2 Antibody

  • 中文名: VAV2抗体
  • 别    名: VAV2; Vav 2 oncogene; VAV-2
货号: IPDX22835
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesVAV2; Vav 2 oncogene; VAV-2
Entrez GeneID7410
WB Predicted band sizeCalculated MW: 101 kDa; Observed MW: 101 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human VAV2
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于VAV2抗体的参考文献示例(注:文献信息为模拟概括,建议通过学术数据库核真实例):

---

1. **文献名称**: *VAV2 signaling regulates regenerative neural growth and functional recovery after spinal cord injury*

**作者**: Smith A, et al.

**摘要**: 研究通过免疫组化(使用VAV2抗体)分析VAV2在小鼠脊髓损伤后轴突再生中的作用,发现VAV2通过激活Rac1通路促进神经修复,抗体特异性验证为其功能研究提供了关键支持。

2. **文献名称**: *Dysregulated VAV2 in HER2-positive breast cancer promotes tumor invasion*

**作者**: Lee J, et al.

**摘要**: 该研究利用VAV2抗体进行Western blot和免疫荧光实验,证实HER2信号通过上调VAV2表达驱动乳腺癌细胞迁移,抗体标记结果与患者预后不良显著相关。

3. **文献名称**: *VAV2 deficiency impairs B-cell receptor internalization and immune synapse formation*

**作者**: Garcia-Saez R, et al.

**摘要**: 通过流式细胞术(依赖VAV2抗体)和基因敲除模型,揭示VAV2在B细胞受体内吞中的关键作用,抗体特异性验证支持了其在免疫突触动态调控中的机制研究。

4. **文献名称**: *Proteomic analysis of VAV2 interactome in pancreatic cancer metastasis*

**作者**: Chen L, et al.

**摘要**: 采用VAV2抗体进行免疫沉淀结合质谱分析,鉴定出VAV2与多种细胞骨架蛋白互作,其表达水平(通过抗体检测)与胰腺癌转移能力正相关。

---

建议通过 **PubMed** 或 **Google Scholar** 搜索关键词“VAV2 antibody”、“VAV2 signaling”等获取具体文献。实际研究中,抗体应用常分布于信号机制、疾病模型或诊断方法学论文中。

背景信息

The VAV2 antibody is a tool used to detect VAV2. a member of the VAV family of guanine nucleotide exchange factors (GEFs). VAV2 plays a critical role in intracellular signaling by activating Rho/Rac GTPases, which regulate cytoskeletal dynamics, cell proliferation, and differentiation. It is ubiquitously expressed and interacts with receptor tyrosine kinases (e.g., EGFR, PDGFR) and cell surface receptors (e.g., T-cell receptors), facilitating signal transduction pathways linked to immune responses, oncogenesis, and cellular motility. Structurally, VAV2 contains conserved domains, including a calponin homology (CH) domain, an acidic domain (AD), a pleckstrin homology (PH) domain, and SH2/SH3 adaptor regions, enabling its role as a scaffold and signaling molecule. Dysregulation of VAV2 is associated with cancers, immune disorders, and neurological diseases. The VAV2 antibody aids in studying its expression, localization, and function in physiological and pathological contexts. Researchers employ it in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore VAV2’s involvement in cellular pathways or disease mechanisms. Its specificity and validation (e.g., knockout controls) ensure reliable detection, supporting advances in understanding VAV2-related signaling networks and therapeutic targeting.

客户数据及评论

折叠内容

大包装询价

×