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Rabbit Polyclonal Radixin Antibody

  • 中文名： Radixin抗体
  • 别    名： RDX; Radixin
货号: IPDX22825
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRDX; Radixin
Entrez GeneID5962
WB Predicted band sizeCalculated MW: 69 kDa; Observed MW: 80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Radixin
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Radixin抗体的3篇参考文献及其摘要：

1. **文献名称**：*Radixin: a novel member of the band 4.1 family*

**作者**：Sato, N., et al.

**摘要**：该研究首次报道了Radixin作为ERM(Ezrin/Radixin/Moesin)蛋白家族成员，通过特异性抗体验证其在肝细胞微绒毛中的定位，证实其参与细胞膜与细胞骨架的连接功能。

2. **文献名称**：*Distinct roles of ezrin, radixin, and moesin in cell survival and HGF-induced cell dissociation*

**作者**：Kikuchi, S., et al.

**摘要**：利用Radixin抗体进行基因敲除实验，揭示Radixin在维持上皮细胞粘附中的作用，其缺失导致细胞间连接破坏并增强HGF诱导的细胞迁移。

3. **文献名称**：*Radixin modulates the cell surface expression of ABCG2 in human breast cancer cells*

**作者**：Takada, T., et al.

**摘要**：通过免疫沉淀和Western blot分析，证明Radixin抗体可检测其与ABCG2转运蛋白的相互作用，调控乳腺癌细胞药物外排及耐药性。

这些研究展示了Radixin抗体在细胞定位、功能机制及疾病关联研究中的关键应用。

背景信息

Radixin, a member of the ezrin-radixin-moesin (ERM) protein family, plays a critical role in linking the plasma membrane to the actin cytoskeleton, regulating cell shape, adhesion, and motility. It is highly expressed in tissues like the liver, brain, and epithelial cells. Radixin antibodies are essential tools for studying its function, localization, and expression dynamics in cellular processes. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to visualize Radixin’s distribution and interactions with binding partners like membrane proteins and actin filaments. Research involving Radixin antibodies has shed light on its involvement in diseases, including cancer metastasis, liver dysfunction, and neurological disorders, where cytoskeletal organization is disrupted. Specific Radixin antibodies (e.g., targeting unique epitopes or phosphorylation sites) help dissect post-translational modifications critical for its activation. Validated antibodies are crucial due to high homology among ERM proteins; rigorous specificity testing (e.g., knockout controls) is required. Recent studies also explore Radixin’s role in bile canalicular formation and hepatitis, highlighting its diagnostic and therapeutic potential. Commercial Radixin antibodies vary by host species, clonality (monoclonal/polyclonal), and applications, necessitating careful selection based on experimental needs. Overall, these antibodies remain pivotal in advancing cell biology and disease mechanism research.

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