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Rabbit Polyclonal CTNNA1 Antibody

  • 中文名： CTNNA1抗体
  • 别    名： Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13
货号: IPDX22824
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCatenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13
Entrez GeneID1495
WB Predicted band sizeCalculated MW: 100 kDa; Observed MW: 100 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Catenin alpha 1
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是模拟生成的关于CTNNA1抗体的参考文献示例(仅供格式参考，非真实文献)：

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1. **"CTNNA1 Antibody Reveals Loss of α-Catenin in Colorectal Cancer Metastasis"**

*Smith J, et al. (2021). Journal of Cancer Research.*

摘要：通过CTNNA1抗体检测发现，结直肠癌组织中α-连环蛋白表达显著降低，与E-cadherin功能失调及肿瘤细胞侵袭性增强相关，提示其在转移中的抑制作用。

2. **"Autoantibody Against CTNNA1 in Dilated Cardiomyopathy"**

*Lee H, et al. (2019). Cardiovascular Pathology.*

摘要：首次报道扩张型心肌病患者血清中存在CTNNA1自身抗体，实验表明该抗体可能破坏心肌细胞间粘附，导致心脏收缩功能异常。

3. **"Development of a High-Specificity CTNNA1 Monoclonal Antibody for Epithelial Studies"**

*Garcia R, et al. (2020). Cell Structure and Function.*

摘要：开发了一种新型CTNNA1单克隆抗体，验证其在免疫组化和Western blot中的高特异性，并用于研究上皮屏障损伤中的α-连环蛋白重分布。

4. **"CTNNA1 Knockout Mice Exhibit Embryonic Defects via Antibody-Based Localization"**

*Chen T, et al. (2022). Developmental Biology.*

摘要：利用CTNNA1抗体进行组织染色，发现敲除小鼠胚胎中细胞粘附缺陷，导致早期发育异常，证实α-连环蛋白对形态发生的关键作用。

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如需实际文献，建议在PubMed、Google Scholar等平台检索关键词“CTNNA1 antibody”及相关研究领域。

背景信息

The CTNNA1 antibody targets the αT-catenin protein encoded by the *CTNNA1* gene, a member of the vinculin/α-catenin family involved in cell-cell adhesion and cytoskeletal organization. αT-catenin is predominantly expressed in cardiac muscle and plays a critical role in maintaining intercalated disc structure and mechanotransduction in cardiomyocytes. Dysregulation or mutations in *CTNNA1* are linked to arrhythmogenic cardiomyopathy (ACM), a heritable heart disorder characterized by fibrofatty myocardial replacement and arrhythmias. Research using CTNNA1 antibodies has elucidated its interaction with desmosomal proteins (e.g., plakoglobin) and adherence junctions, highlighting its importance in cardiac tissue integrity. Beyond cardiology, CTNNA1 has tumor-suppressive roles in epithelial cancers, where loss of expression correlates with metastasis and poor prognosis. Commercially available CTNNA1 antibodies are used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to assess protein localization, expression levels, and pathological alterations in tissues or cell models. Recent studies also explore its role in signaling pathways (e.g., Wnt/β-catenin) and mechanosensitive processes. Validating antibody specificity remains crucial due to homology with other catenins. Overall, CTNNA1 antibodies serve as vital tools in cardiovascular research, oncology, and studies of cell adhesion mechanisms.

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