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Rabbit Polyclonal STK3 Antibody

  • 中文名： STK3抗体
  • 别    名： STK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2
货号: IPDX22818
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSTK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2
Entrez GeneID6788
WB Predicted band sizeCalculated MW: 56 kDa; Observed MW: 56 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human STK3
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于STK3抗体的3篇示例参考文献(仅供参考，具体文献需通过学术数据库核实)：

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1. **文献名称**：*STK3/MST2 Regulates Cell Proliferation and Apoptosis via the Hippo Signaling Pathway*

**作者**：Pan D. et al.

**摘要**：本研究利用STK3特异性抗体，通过免疫印迹和免疫沉淀技术，揭示了STK3(MST2)在Hippo信号通路中通过磷酸化下游效应蛋白YAP，调控细胞增殖和凋亡的分子机制，尤其在肝癌模型中表现出抑癌作用。

2. **文献名称**：*STK3 Deficiency Promotes Colorectal Cancer Metastasis through YAP Activation*

**作者**：Johnson R. et al.

**摘要**：通过STK3抗体敲低实验，研究发现STK3缺失导致Hippo通路失活，YAP核内积累，进而促进结直肠癌细胞的侵袭和转移，提示STK3作为潜在转移抑制因子的作用。

3. **文献名称**：*Antibody-Based Targeting of STK3 Enhances Chemotherapy Sensitivity in Breast Cancer*

**作者**：Zhang L. et al.

**摘要**：该研究开发了一种高特异性STK3单克隆抗体，证实其可通过抑制STK3激酶活性增强乳腺癌细胞对化疗药物的敏感性，为联合治疗提供了实验依据。

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**注**：以上文献为模拟示例，实际引用时请通过PubMed、Google Scholar等平台检索真实文献，并核对作者及摘要准确性。

背景信息

The serine/threonine kinase 3 (STK3), also known as mammalian sterile 20-like kinase 2 (MST2), is a key component of the Hippo signaling pathway, which regulates organ size, cell proliferation, apoptosis, and tissue homeostasis. STK3 functions as a tumor suppressor by phosphorylating downstream effectors like LATS1/2. leading to inhibition of YAP/TAZ oncoproteins. Dysregulation of STK3 is implicated in cancer development, metabolic disorders, and neurodegenerative diseases. Antibodies targeting STK3 are essential tools for studying its expression, localization, and activity in cellular and disease contexts. These antibodies enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They are also used to investigate post-translational modifications, protein-protein interactions (e.g., with RASSF1A or Sav1), and pathway dynamics in response to stressors like DNA damage or metabolic changes. STK3 antibodies are often validated using knockout cell lines or tissues to ensure specificity. Commercial antibodies may target distinct epitopes, such as the kinase domain or regulatory regions, to support functional studies. Research involving STK3 antibodies has advanced understanding of Hippo pathway crosstalk with other signaling networks (e.g., Wnt, TGF-β) and its therapeutic potential in precision oncology. Challenges include distinguishing STK3 from its homolog STK4 (MST1) due to their structural similarity, emphasizing the need for antibody validation.

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