| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PHA; LMN2R; TDRD18; DHCR14B; LBR |
| Entrez GeneID | 3930 |
| WB Predicted band size | Calculated MW: 71 kDa; Observed MW: 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human Lamin B Receptor |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于Lamin B Receptor(LBR)抗体的参考文献及其摘要概括：
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1. **文献名称**: *"The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains"*
**作者**: Ye Q., Worman H.J.
**摘要**: 该研究首次克隆并鉴定了LBR的分子结构，指出其作为核膜内层蛋白的跨膜特性。研究利用特异性抗体证实了LBR在核膜中的定位，并发现其与染色质和核纤层的相互作用。
2. **文献名称**: *"Immunolocalization of lamin B receptor in mammalian cells and its role in chromatin organization"*
**作者**: Pyrpasopoulou A., et al.
**摘要**: 通过免疫荧光和免疫电镜技术，研究揭示了LBR抗体在多种哺乳动物细胞中的染色模式，证明LBR参与细胞分裂期的核膜重组和间期染色质的空间排布。
3. **文献名称**: *"Lamin B receptor mutations in Pelger-Huët anomaly and related hypolobulated neutrophil disorders"*
**作者**: Hoffmann K., et al.
**摘要**: 研究通过LBR抗体检测发现，Pelger-Huët异常(一种白细胞形态缺陷疾病)患者的LBR基因存在突变，导致核膜结构异常，验证了LBR在粒细胞分化中的关键作用。
4. **文献名称**: *"Antibody-based analysis of lamin B receptor function in nuclear envelope assembly"*
**作者**: Olins A.L., et al.
**摘要**: 研究使用LBR抗体阻断实验，证明LBR在有丝分裂后核膜重建过程中不可或缺，并揭示其通过结合组蛋白H3/H4参与染色质锚定和核膜组装。
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以上文献涵盖了LBR抗体的基础研究、结构分析、疾病关联及功能验证，可作为相关领域的参考。
The lamin B receptor (LBR) is a multifunctional transmembrane protein located in the inner nuclear membrane, playing critical roles in nuclear architecture, chromatin organization, and cell cycle regulation. It binds to lamin B, a key component of the nuclear lamina, and interacts with heterochromatin to maintain nuclear envelope stability and mediate tethering of chromatin to the periphery. LBR also exhibits sterol reductase activity, contributing to cholesterol biosynthesis. Dysregulation of LBR is linked to human diseases, including Pelger-Huët anomaly (a blood disorder marked by abnormal neutrophil nuclei) and rare skeletal dysplasias like Greenberg dysplasia.
Antibodies targeting LBR are essential tools for studying its localization, expression, and molecular interactions. They are widely used in techniques such as immunofluorescence, Western blotting, and chromatin immunoprecipitation to investigate nuclear envelope dynamics, mitotic nuclear membrane breakdown/reassembly, and epigenetic regulation. In clinical research, LBR antibodies aid in diagnosing genetic disorders and probing pathological mechanisms related to nuclear lamina defects. Recent studies also explore LBR's role in aging, cancer, and viral infections, where nuclear envelope integrity influences disease progression. These antibodies thus serve as vital reagents for unraveling both basic nuclear biology and disease-associated pathways.
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