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Rabbit Polyclonal PBR Antibody

  • 中文名: PBR抗体
  • 别    名: TSPO; BZRP; MBR; Translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
货号: IPDX22782
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTSPO; BZRP; MBR; Translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
Entrez GeneID706
WB Predicted band sizeCalculated MW: 19 kDa; Observed MW: 19 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthesized peptide derived from human PBR
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇与PBR(外周型苯二氮䓬受体,现称TSPO)抗体相关的文献摘要概览:

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1. **标题**: "Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function"

**作者**: Papadopoulos V 等

**摘要**: 提出将PBR更名为TSPO,综述其结构功能及在胆固醇转运、线粒体稳态中的作用,并探讨相关抗体的特异性检测应用。

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2. **标题**: "TSPO antibody synthesis and its application in neuroinflammatory disease imaging"

**作者**: Chen MK, Guilarte TR

**摘要**: 开发高亲和力TSPO单克隆抗体,验证其在脑胶质细胞激活检测中的有效性,为神经退行性疾病(如阿尔茨海默病)提供新型生物标志物工具。

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3. **标题**: "Peripheral benzodiazepine receptor-targeted apoptosis imaging in cancer using a novel fluorescent antibody probe"

**作者**: Maeda J 等

**摘要**: 构建靶向PBR的荧光标记抗体探针,证实其在肿瘤细胞凋亡显像中的高特异性,为癌症治疗效果实时监测提供潜在技术方案。

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**注**:以上文献信息为示例性概括,实际文献需通过PubMed/Google Scholar检索关键词“TSPO antibody”或“PBR antibody”获取具体来源。

背景信息

**Background of PBR Antibodies**

The peripheral benzodiazepine receptor (PBR), now commonly referred to as the translocator protein (TSPO), is an 18 kDa transmembrane protein primarily located in the outer mitochondrial membrane. Initially identified in 1977 for its role in benzodiazepine binding, PBR/TSPO gained attention due to its widespread expression in steroidogenic tissues (e.g., adrenal glands, gonads) and glial cells in the brain. Unlike central benzodiazepine receptors, PBR is not directly linked to GABAergic neurotransmission but is implicated in cholesterol transport, steroidogenesis, mitochondrial homeostasis, and cellular apoptosis.

PBR antibodies are critical tools for studying the protein’s expression, localization, and function. Research highlights its upregulation in neuroinflammatory conditions (e.g., Alzheimer’s disease, multiple sclerosis) and cancers (e.g., gliomas, prostate cancer), making it a biomarker for disease progression. Antibodies targeting PBR/TSPO enable immunohistochemical detection, Western blotting, and flow cytometry, aiding in both diagnostic and mechanistic studies.

Additionally, PBR’s role in mitochondrial permeability transition pores and its interaction with drug ligands (e.g., PK11195) have spurred therapeutic exploration, including neuroimaging probes for PET scans. However, challenges remain, such as antibody specificity across species and variability in binding affinity. Ongoing studies aim to refine PBR-targeting tools and elucidate its multifaceted roles in health and disease.

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