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Rabbit Monoclonal NMDAR2A Antibody

  • 中文名： NMDAR2A抗体
  • 别    名： NR2A; GluN2A; NMDAR2A; GluRepsilon1
货号: IPDX22718
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Mouse,Rat
IF 咨询技术 Mouse,Rat
IHC 咨询技术 Mouse,Rat
ICC 技术咨询 Mouse,Rat
FCM 咨询技术 Mouse,Rat
Elisa 咨询技术 Mouse,Rat

产品详情

AliasesNR2A; GluN2A; NMDAR2A; GluRepsilon1
Entrez GeneID14811
WB Predicted band sizeCalculated MW: 165 kDa; Observed MW: 165 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse,Rat
ImmunogenRecombinant protein of mouse NMDAR2A
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于NMDAR2A抗体的3篇模拟参考文献示例(实际文献需通过学术数据库查询)：

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1. **文献名称**: *Anti-NMDA Receptor Encephalitis: Clinical Phenotypes and Antibody Effects*

**作者**: Dalmau J, et al.

**摘要**: 研究NMDAR2A抗体在抗NMDA受体脑炎中的致病机制，发现抗体通过结合神经元表面NMDAR2A亚基，导致受体内化并抑制突触传递，引发认知障碍和精神症状。

2. **文献名称**: *Autoantibodies to NMDA Receptor GluN2A Subunit in Neuropsychiatric Disorders*

**作者**: Gresa-Arribas N, et al.

**摘要**: 通过ELISA和细胞实验，验证NMDAR2A抗体在部分精神分裂症和癫痫患者中的存在，提示其可能通过干扰谷氨酸信号通路参与疾病发生。

3. **文献名称**: *Structural Insights into NMDAR2A Antibody Binding Epitopes*

**作者**: Hughes EG, et al.

**摘要**: 利用冷冻电镜技术解析NMDAR2A抗体与受体结合的分子结构，揭示其靶向受体N端结构域的抗原表位，为特异性抗体检测提供理论依据。

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**注**：以上为模拟简化版摘要，实际文献请通过PubMed、Google Scholar等平台查询关键词如"anti-NMDAR2A antibody"或"NMDAR encephalitis"。抗NMDAR脑炎的核心研究可参考Dalmau团队发表于*Lancet Neurology*的临床综述。

背景信息

The N-methyl-D-aspartate receptor 2A (NMDAR2A, also called GluN2A) antibody is a laboratory tool targeting the GluN2A subunit of NMDA receptors, ionotropic glutamate receptors critical for synaptic plasticity, learning, and memory. NMDARs are heterotetramers typically composed of two GluN1 and two GluN2 subunits (GluN2A-D). The GluN2A subunit, encoded by GRIN2A, influences receptor kinetics, calcium permeability, and synaptic localization. Anti-NMDAR2A antibodies are primarily used in research to study receptor distribution, trafficking, and function in neurological disorders. Clinically, autoantibodies against NMDAR (often targeting GluN1 subunits) are linked to autoimmune encephalitis, but GluN2A-specific autoantibodies are less common and associated with distinct neurological manifestations, including seizures and cognitive deficits. Commercial NMDAR2A antibodies are generated in animals using peptide immunogens, validated via techniques like immunoblotting, immunohistochemistry, or knockout controls. They enable investigations into NMDAR dysregulation in conditions like epilepsy, Alzheimer’s disease, and schizophrenia. However, cross-reactivity with other GluN2 subunits remains a validation challenge. In diagnostics, detecting anti-NMDAR2A autoantibodies in serum or cerebrospinal fluid (CSF) requires cell-based assays (CBA) to confirm specificity. Research applications also extend to neurodevelopmental studies, as GluN2A expression increases during synaptic maturation.

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