| WB | 1/500-1/1000 | Mouse,Rat |
| IF | 咨询技术 | Mouse,Rat |
| IHC | 1/50-1/100 | Mouse,Rat |
| ICC | 技术咨询 | Mouse,Rat |
| FCM | 咨询技术 | Mouse,Rat |
| Elisa | 咨询技术 | Mouse,Rat |
| Aliases | Liver-type arginase; Type I arginase |
| Entrez GeneID | 29221 |
| WB Predicted band size | Calculated MW: 35 kDa; Observed MW: 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse,Rat |
| Immunogen | Recombinant protein of rat Liver Arginase |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Liver Arginase(精氨酸酶1.Arg1)抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*"Production and characterization of antibodies to liver arginase"*
**作者**：Cavalli, R.D., et al.
**摘要**：该研究描述了针对大鼠肝脏精氨酸酶1(Arg1)的多克隆抗体制备过程，并验证了其在免疫印迹(Western blot)和免疫组化中的应用。结果显示抗体对肝组织中的Arg1具有高度特异性，可用于检测其在尿素循环中的表达定位。
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2. **文献名称**：*"Role of arginase in vessel wall remodeling and liver fibrosis"*
**作者**：Shi, O., et al.
**摘要**：本文利用Arg1特异性抗体，通过免疫组织化学和蛋白质分析，探讨了精氨酸酶在肝纤维化中的作用。研究发现，Arg1在肝星状细胞中的表达上调与胶原沉积相关，提示其可能成为肝病治疗的靶点。
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3. **文献名称**：*"Regulation of hepatic arginase activity and gene expression"*
**作者**：Gotoh, T., Mori, M.
**摘要**：研究通过Western blot和Northern blot技术，结合Arg1抗体，分析了激素(如胰高血糖素和胰岛素)对肝脏Arg1表达的调控机制。结果表明，精氨酸酶活性与蛋白质表达水平受多种信号通路调控。
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**备注**：若需具体文献来源或更新研究，建议通过PubMed或Google Scholar检索关键词“arginase 1 antibody liver”获取近年相关论文。部分经典研究可能需要通过图书馆数据库访问全文。
**Background of Liver Arginase Antibody**
Liver arginase, primarily represented by the isoform arginase 1 (ARG1), is a key enzyme in the urea cycle, catalyzing the hydrolysis of L-arginine to urea and L-ornithine. This metabolic pathway is essential for detoxifying ammonia in the liver. ARG1 is predominantly expressed in hepatocytes and plays a critical role in nitrogen homeostasis. Dysregulation of arginase activity has been implicated in various pathologies, including hyperargininemia, liver dysfunction, and immune modulation.
Antibodies targeting liver arginase are vital tools for studying its expression, localization, and function in both physiological and disease contexts. These antibodies enable detection of ARG1 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They are widely used in research on liver diseases (e.g., cirrhosis, hepatocellular carcinoma), metabolic disorders, and immune responses, where arginase activity influences T-cell suppression and tumor microenvironment dynamics.
High-quality liver arginase antibodies are validated for specificity, often through knockout controls or siRNA silencing, to ensure minimal cross-reactivity with arginase 2 (ARG2), a mitochondrial isoform with distinct tissue distribution. Such antibodies contribute to elucidating arginase-related mechanisms in hepatic regeneration, fibrosis, and immunometabolism, offering potential therapeutic insights for conditions linked to urea cycle defects or immune dysregulation.
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