| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LDHA; LDH-M; LDH1; PIG19; GSD11; TRG5; Proliferation inducing gene 19 |
| Entrez GeneID | 3939 |
| WB Predicted band size | Calculated MW: 37 kDa; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Lactate Dehydrogenase |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于乳酸脱氢酶A(LDHA)抗体的参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *Targeting lactate dehydrogenase A inhibits tumorigenesis and tumor progression in mouse models of lung cancer*
**作者**: Xie H, et al.
**摘要**: 本研究利用LDHA特异性抗体验证了LDHA在肺癌小鼠模型中的高表达，并通过抑制LDHA活性显著减少了肿瘤生长和转移，表明LDHA可能作为肺癌治疗的潜在靶点。
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2. **文献名称**: *LDHA-associated lactic acid production promotes immune evasion by dampening glycolytic metabolism in cytotoxic T cells*
**作者**: Angelin A, et al.
**摘要**: 通过LDHA抗体检测发现，肿瘤微环境中乳酸水平升高抑制了T细胞的糖代谢活性，揭示了LDHA介导的免疫逃逸机制，为联合靶向LDHA与免疫治疗提供了依据。
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3. **文献名称**: *A monoclonal antibody-based ELISA for quantification of LDHA in human serum: applications in cancer diagnosis*
**作者**: Chen Y, et al.
**摘要**: 该研究开发了一种基于LDHA单克隆抗体的ELISA检测方法，证实血清LDHA水平与结直肠癌患者分期呈正相关，提示其作为癌症无创诊断标志物的潜力。
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**备注**：以上文献可在PubMed、Web of Science等平台通过标题或作者检索原文。如需更多文献或具体发表年份，建议进一步筛选数据库。
Lactate dehydrogenase A (LDHA) is a critical enzyme in the glycolytic pathway, catalyzing the conversion of pyruvate to lactate while regenerating NAD⁺ to sustain anaerobic glycolysis. This isoform is highly expressed in tissues with high energy demands, such as skeletal muscle, and is notably upregulated in cancer cells due to the Warburg effect, a metabolic shift favoring glycolysis even under aerobic conditions. LDHA supports tumor progression by promoting acidification of the tumor microenvironment, angiogenesis, and resistance to apoptosis.
LDHA antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess LDHA levels in cancer biopsies, aiding in prognosis and therapeutic targeting. Research has linked elevated LDHA expression to poor clinical outcomes in various cancers, including breast, lung, and colorectal carcinomas. Additionally, LDHA antibodies help investigate metabolic adaptations in non-cancerous conditions like ischemia and inflammatory diseases. Recent studies also explore LDHA's role in immune cell metabolism and its potential as a biomarker for metabolic dysfunction. Inhibitors targeting LDHA are under development, highlighting the antibody's utility in validating drug efficacy and mechanistic studies.
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