关键信息
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基因名
CADM1/IGSF4A
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简介
CADM1/IGSF4A proteins coordinate Ca(2+)-independent homophilic and heterophilic cell adhesion with CADM3 and NECTIN3. Interaction with CRTAM enhances NK cell cytotoxicity and CD8+ T cell function. CADM1/IGSF4A Protein, Mouse (341a.a, HEK293, His) is the recombinant mouse-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-6*His labeled tag.
- 应用
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别名
rMuCell adhesion molecule 1/CADM1, His; Cell adhesion molecule 1; Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8R5M8-1
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表达区间
Q48-H388
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氨基酸序列
QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAFELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGTIGAVDH
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蛋白长度
Extracellular Domain
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分子量
60-100 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CADM1, also known as Cell Adhesion Molecule 1, and IGSF4A, an Immunoglobulin Superfamily member 4A, are crucial components in cellular adhesion and communication processes, particularly in the nervous system and immune responses. CADM1 is implicated in synaptic plasticity, neuronal development, and tumor suppression, while IGSF4A plays roles in regulating cell junctions and signaling pathways. The study of CADM1 and IGSF4A recombinant proteins has gained significant attention due to their potential applications in understanding various diseases, including cancer and neurodegenerative disorders. By producing and analyzing these recombinant proteins, researchers aim to elucidate their structural properties, functional mechanisms, and interactions with other cellular components. This research not only enhances our knowledge of cell adhesion and communication but also opens avenues for therapeutic interventions targeting CADM1 and IGSF4A in disease contexts. The insights gained from studying these proteins may lead to novel biomarker discoveries and strategies for drug development. Therefore, the exploration of CADM1/IGSF4A recombinant proteins holds promise for advancing biomedical science and improving treatment options for various pathologies.
