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Rabbit Monoclonal Adiponectin Antibody

  • 中文名： Adiponectin抗体
  • 别    名： Ad; APN; Acdc; Adid; apM1; 30kDa; GBP28; adipo; Acrp30
货号: IPDX22689
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Mouse,Rat
IF 咨询技术 Mouse,Rat
IHC 1/50-1/100 Mouse,Rat
ICC 1/50-1/200 Mouse,Rat
FCM 咨询技术 Mouse,Rat
Elisa 咨询技术 Mouse,Rat

产品详情

AliasesAd; APN; Acdc; Adid; apM1; 30kDa; GBP28; adipo; Acrp30
Entrez GeneID11450
WB Predicted band sizeCalculated MW: 27 kDa; Observed MW: 30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse,Rat
ImmunogenRecombinant protein of mouse Adiponectin
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于Adiponectin抗体的3篇参考文献及其摘要内容：

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1. **文献名称**: *"Adiponectin Antibody-Based ELISA for the Measurement of Adiponectin in Human Serum"*

**作者**: Arita Y., et al.

**摘要**: 该研究开发了一种基于单克隆抗体的ELISA检测方法，用于定量人血清中的Adiponectin，验证了其高灵敏度和特异性，并发现Adiponectin水平与肥胖及胰岛素抵抗呈负相关。

2. **文献名称**: *"Role of Adiponectin in Cardiovascular Diseases: Insights from Adiponectin Knockout Mice"*

**作者**: Hotta K., et al.

**摘要**: 通过使用Adiponectin基因敲除小鼠模型及特异性抗体检测，研究揭示了Adiponectin缺失导致血管内皮功能异常和动脉粥样硬化加速，强调了其对心血管保护的作用机制。

3. **文献名称**: *"Structural and Functional Analysis of Adiponectin Antibodies in Type 2 Diabetes Research"*

**作者**: Kadowaki T., et al.

**摘要**: 该文献系统评价了多种Adiponectin抗体在糖尿病研究中的应用，发现不同表位抗体对Adiponectin全聚体/低聚体的检测差异，并探讨其在临床样本中的病理意义。

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**备注**：以上文献为示例，实际引用时请核对真实存在的论文信息及数据库来源(如PubMed、ScienceDirect)。

背景信息

Adiponectin antibodies are essential tools for studying adiponectin, a hormone predominantly secreted by adipose tissue that plays a critical role in regulating glucose metabolism, fatty acid oxidation, and insulin sensitivity. Adiponectin exists in multiple oligomeric forms, including low-, medium-, and high-molecular-weight complexes, each with distinct biological activities. Its circulating levels are inversely correlated with obesity, type 2 diabetes, and cardiovascular diseases, making it a key biomarker in metabolic research. Antibodies targeting adiponectin enable the detection, quantification, and functional analysis of this protein in various experimental settings, such as Western blotting, ELISA, immunohistochemistry, and flow cytometry. These antibodies are designed to recognize specific epitopes on adiponectin, often differentiating between its globular and full-length isoforms or its oligomeric states. Both monoclonal and polyclonal variants are available, with monoclonal antibodies offering higher specificity and polyclonal antibodies providing broader epitope recognition. Validation of adiponectin antibodies is crucial, as cross-reactivity with related proteins (e.g., collagens or complement factors) can occur due to structural similarities. Researchers use these antibodies to explore adiponectin's roles in inflammation, energy homeostasis, and tissue repair, as well as to investigate therapeutic strategies targeting adipokine signaling pathways. Their application extends to clinical diagnostics, where measuring adiponectin levels aids in assessing metabolic health and disease risk.

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