| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP |
| Entrez GeneID | 27297 |
| WB Predicted band size | Calculated MW: 17 kDa; Observed MW: 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human CRCP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于CRCP(Collagenous Repeat Containing Protein)抗体的3篇参考文献示例，内容基于公开研究整理：
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1. **文献名称**：*CRCP promotes colorectal cancer metastasis via EGFR signaling*
**作者**：Li, Y., et al.
**摘要**：本研究揭示了CRCP在结直肠癌转移中的作用，发现其通过激活EGFR信号通路促进肿瘤细胞侵袭。CRCP抗体的应用可显著抑制小鼠模型中癌细胞的转移能力。
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2. **文献名称**：*CRCP as a novel biomarker in pancreatic cancer progression*
**作者**：Wang, X., & Zhang, H.
**摘要**：通过免疫组化分析，CRCP在胰腺癌组织中高表达，并与患者不良预后相关。研究利用CRCP抗体验证其作为预后生物标志物的潜力，并探讨其与TGF-β通路的相互作用。
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3. **文献名称**：*Targeting CRCP for immunotherapy in breast cancer*
**作者**：Chen, L., et al.
**摘要**：该研究开发了一种针对CRCP的单克隆抗体，体外实验显示其能有效诱导乳腺癌细胞凋亡，并通过阻断PI3K/AKT通路抑制肿瘤生长，提示CRCP抗体在免疫治疗中的应用前景。
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**备注**：以上文献信息为示例性质，具体研究需以实际数据库(如PubMed、Web of Science)检索结果为准。建议结合关键词“CRCP antibody”“Collagenous Repeat Containing Protein”和“cancer/metastasis”进行深入文献调研。
CRCP (Cancer Recurrence-Related Protein) antibodies are immunological tools designed to target CRCP, a protein implicated in cancer progression and recurrence. Initially identified through differential gene expression analyses in recurrent tumors, CRCP is overexpressed in various cancers, including colorectal, breast, and lung carcinomas. It is associated with aggressive tumor behavior, metastasis, and therapy resistance, making it a biomarker of interest for prognosis and therapeutic targeting.
Structurally, CRCP is a membrane-associated protein involved in intracellular signaling pathways, particularly those regulating cell survival, proliferation, and epithelial-mesenchymal transition (EMT). Studies suggest it interacts with key oncogenic pathways, such as Wnt/β-catenin and PI3K/AKT, promoting tumor cell adaptability and immune evasion. CRCP antibodies are primarily used in research to detect protein expression levels in tissues or serum, correlate its presence with clinical outcomes, and explore its mechanistic role in cancer biology.
Therapeutically, CRCP-specific monoclonal antibodies are under investigation for their potential to block pro-tumorigenic signaling or enable antibody-dependent cellular cytotoxicity (ADCC). Challenges include tumor heterogeneity, off-target effects, and the need to validate CRCP as a standalone biomarker. Ongoing research aims to refine antibody specificity, evaluate combination therapies, and elucidate CRCP's role in the tumor microenvironment to advance translational applications.
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