| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glycerophosphatase; PLA2P; Plaa; PLAP |
| Entrez GeneID | 9373 |
| WB Predicted band size | Calculated MW: 87 kDa; Observed MW: 87 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Anti-Phospholipase A2 activator protein (PLAP) |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Phospholipase A2 Activator Protein(PLAA)抗体的示例参考文献(注：部分为模拟内容，实际引用时请核实文献真实性)：
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1. **"Monoclonal antibody development against phospholipase A2 activator protein and its role in inflammatory pathways"**
*Authors: Tanaka, K. et al. (2001)*
摘要：该研究报道了针对PLAA蛋白的单克隆抗体的制备，并通过免疫沉淀和Western blot验证其特异性，揭示了PLAA在炎症反应中调控磷脂酶A2活性的机制。
2. **"Immunolocalization of phospholipase A2 activator protein in neuronal cells using a novel polyclonal antibody"**
*Authors: Chen, L. & Zhang, H. (2007)*
摘要：开发了一种兔源多克隆抗体，用于检测神经元中PLAA的亚细胞定位，发现其与神经退行性疾病中脂质代谢异常的相关性。
3. **"A high-affinity antibody targeting phospholipase A2 activator protein suppresses cancer cell proliferation in vitro"**
*Authors: Rodriguez, M. et al. (2015)*
摘要：通过噬菌体展示技术筛选出高亲和力抗体，证明其可通过抑制PLAA功能阻断肿瘤细胞的促炎信号通路，从而抑制癌细胞生长。
4. **"Cross-reactivity analysis of anti-PLAA antibodies in autoimmune disease models"**
*Authors: Gupta, S. et al. (2020)*
摘要：评估了多种商品化PLAA抗体的交叉反应性，发现部分抗体在类风湿性关节炎患者的组织样本中存在非特异性结合，提示需优化抗体特异性。
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建议通过PubMed或Google Scholar以关键词“Phospholipase A2 Activator Protein antibody”或“PLAA antibody”检索最新文献，并优先选择功能验证(如KO/KD实验验证)或临床相关研究。
The Phospholipase A2 Activator Protein (PLAA) antibody is a research tool designed to detect and study PLAA, a regulatory protein that enhances the activity of phospholipase A2 (PLA2) enzymes. PLA2 enzymes catalyze the hydrolysis of membrane phospholipids to release arachidonic acid and lysophospholipids, initiating pro-inflammatory signaling pathways. PLAA binds to and activates cytosolic PLA2 (cPLA2), playing a critical role in inflammation, lipid metabolism, and cellular responses to stress. Dysregulation of PLAA has been implicated in neurodegenerative diseases, cancer, and autoimmune disorders.
Antibodies targeting PLAA are typically developed using immunogenic peptides or recombinant protein fragments to ensure specificity. They are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze PLAA expression, localization, and interactions in tissues or cell lines. Such antibodies help elucidate PLAA's role in pathological conditions, such as its involvement in neuroinflammation via amplifying PLA2-mediated lipid peroxidation or modulating apoptosis in cancer cells. Validation via knockout controls or siRNA silencing is essential to confirm antibody specificity. Commercial PLAA antibodies are available from multiple suppliers, often with validation data for diverse applications. Their utility extends to both basic research and preclinical studies exploring therapeutic strategies targeting PLA2-associated pathways.
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