关键信息
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基因名
HIST1H2AJ
- 应用
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别名
H2AFE; H2A/E; H2A Histone Family Member E
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99878
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表达区间
Met1~Lys128
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
HIST1H2AJ is a member of the histone H2A family, playing a critical role in the formation of nucleosomes, which are the basic units of chromatin structure in eukaryotic cells. Histones, including HIST1H2AJ, are pivotal in regulating DNA packaging and accessibility, thereby influencing gene expression and cellular processes such as replication, transcription, and DNA repair. Recent studies have highlighted the significance of HIST1H2AJ in various biological contexts, including its involvement in tumorigenesis and cellular response to stress. The protein's unique structural features and post-translational modifications are also under investigation to understand their implications in epigenetic regulation. With the advent of advanced biotechnological tools, including CRISPR-Cas9 and protein engineering techniques, researchers are now able to create recombinant versions of HIST1H2AJ to explore its functional properties in a controlled manner. This research aims to elucidate the specific contributions of HIST1H2AJ to chromatin dynamics and cell fate decisions, offering potential insights into therapeutic targets for cancer and other diseases associated with epigenetic dysregulation. As the understanding of this histone variant expands, it holds promise for unraveling the complexities of genomic organization and the regulation of biological processes fundamental to life.
