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Rabbit Monoclonal VAV2 Antibody

  • 中文名： VAV2抗体
  • 别    名： VAV2; Vav 2 oncogene; VAV-2
货号: IPDX22629
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesVAV2; Vav 2 oncogene; VAV-2
Entrez GeneID7410
WB Predicted band sizeCalculated MW: 101 kDa; Observed MW: 101 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human VAV2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于VAV2抗体的3篇参考文献，涵盖其在不同研究中的应用和发现：

1. **文献名称**：*VAV2 signaling promotes regenerative proliferation in both cutaneous and corneal epithelial wound healing*

**作者**：Liu S, et al.

**摘要**：研究利用VAV2抗体检测皮肤和角膜上皮细胞中VAV2蛋白的表达，发现VAV2通过激活RAC1信号通路促进上皮再生，为组织修复机制提供新见解。

2. **文献名称**：*VAV2 oncogenic mutation enhances thyroid cancer invasion by modulating F-actin organization and focal adhesion dynamics*

**作者**：Garcia-Rendueles MER, et al.

**摘要**：通过免疫沉淀和Western blot(使用VAV2抗体)发现VAV2突变体增强甲状腺癌细胞侵袭能力，揭示了其通过调控细胞骨架重塑促进肿瘤转移的机制。

3. **文献名称**：*VAV2 deficiency in macrophages promotes adipose tissue inflammation and insulin resistance*

**作者**：Meng F, et al.

**摘要**：研究通过免疫组化(VAV2抗体)证实巨噬细胞中VAV2缺失导致脂肪组织炎症因子增加，阐明了VAV2在代谢稳态中的关键调控作用。

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**备注**：若需具体期刊信息或发表年份，可进一步补充关键词或研究领域缩小范围。

背景信息

The VAV2 antibody is a research tool used to detect and study the VAV2 protein, a member of the VAV family of guanine nucleotide exchange factors (GEFs). VAV2 plays a critical role in intracellular signaling pathways, particularly those regulating actin cytoskeleton reorganization, cell migration, and immune responses. It activates Rho/Rac GTPases by facilitating the exchange of GDP for GTP, thereby influencing cellular processes like proliferation, differentiation, and apoptosis. VAV2 is expressed in various tissues, with notable roles in immune cells, where it mediates signaling from receptors such as T-cell and B-cell antigen receptors. Dysregulation of VAV2 has been implicated in cancers, neurological disorders, and autoimmune diseases, making it a target for therapeutic research. The VAV2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate its expression, localization, and interaction partners. Researchers also employ it to explore VAV2's phosphorylation-dependent activation mechanisms, often triggered by tyrosine kinases. Understanding VAV2's functions through antibody-based studies contributes to deciphering its pathological roles and potential as a biomarker or drug target.

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