关键信息
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基因名
Sorcin/SRI
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简介
The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (E.coli, GST) is the recombinant human-derived Sorcin/SRI protein, expressed by E. coli , with N-GST labeled tag.
- 应用
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别名
22 kDa protein; CP22; V19
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种属
Human
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表达系统
E. coli
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30626
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表达区间
M1-V198
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Sorcin, also known as SRI (Stress-Response Protein), is a calcium-binding protein belonging to the S100 family that plays a critical role in various cellular processes, including calcium homeostasis, cell proliferation, and apoptosis. Research into Sorcin has gained momentum due to its involvement in the regulation of heart function and its potential link to various pathologies, such as cancer and cardiac diseases. In particular, Sorcin has been implicated in the development of drug resistance in cancer cells, making it a target of interest in the field of cancer therapeutics. The recombinant expression of Sorcin facilitates detailed studies of its structure and function, allowing for the characterization of its interaction with calcium ions and other cellular components. The ability to produce recombinant Sorcin in a controlled environment provides an opportunity to explore its biochemical properties and functional mechanisms further, with potential applications in drug development and disease therapeutics. Overall, the investigation of Sorcin/SRI recombinant protein is crucial for understanding its role in health and disease, which may lead to novel therapeutic strategies targeting its signaling pathways.
