| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UBCH 10; UbcH10; Ube2c |
| Entrez GeneID | 11065 |
| WB Predicted band size | Calculated MW: 20 kDa; Observed MW: 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human UBE2C |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于UBE2C抗体的3篇参考文献示例，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: "UBE2C is a potential biomarker for aggressive breast cancer"
**作者**: Wang et al.
**摘要**: 该研究利用UBE2C特异性抗体通过免疫组化分析乳腺癌组织，发现UBE2C高表达与肿瘤分级、转移及患者生存率下降显著相关，提示其作为乳腺癌预后标志物的潜力。
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2. **文献名称**: "UBE2C promotes hepatocellular carcinoma progression via ubiquitination of p53"
**作者**: Li et al.
**摘要**: 通过Western blot和免疫共沉淀实验(使用UBE2C抗体)，研究发现UBE2C通过泛素化修饰p53并促进其降解，从而驱动肝癌细胞增殖和化疗耐药。
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3. **文献名称**: "The role of UBE2C in cell cycle regulation and genomic instability"
**作者**: Peters et al.
**摘要**: 利用UBE2C抗体进行细胞周期同步化实验，证实UBE2C在中期-后期转换中调控Cyclin B1稳定性，其异常表达导致染色体分离错误和基因组不稳定性。
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(注：以上文献为示例，实际引用需以具体论文内容为准。)
The Ubiquitin Conjugating Enzyme E2 C (UBE2C), a member of the E2 ubiquitin-conjugating enzyme family, plays a critical role in the ubiquitin-proteasome system (UPS), which regulates protein degradation and cellular homeostasis. UBE2C specifically interacts with E3 ubiquitin ligases, such as the anaphase-promoting complex/cyclosome (APC/C), to mediate the transfer of ubiquitin to target proteins. This process is essential for cell cycle progression, particularly during mitosis, where UBE2C facilitates the degradation of key regulatory proteins like securin and cyclin B, enabling proper chromosome segregation and mitotic exit. Dysregulation of UBE2C has been linked to genomic instability, uncontrolled cell proliferation, and cancer progression.
Antibodies targeting UBE2C are widely used in research to investigate its expression, localization, and function in both normal and pathological contexts. Overexpression of UBE2C is observed in various cancers, including breast, colorectal, and lung carcinomas, correlating with poor prognosis and therapeutic resistance. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding studies on UBE2C’s role in tumorigenesis, cell cycle dysregulation, and response to UPS-targeted therapies. Additionally, UBE2C antibodies are valuable tools for exploring its potential as a biomarker or therapeutic target in precision oncology. Their specificity and reliability are critical for elucidating molecular mechanisms underlying diseases associated with ubiquitination defects.
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