| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SAA |
| WB Predicted band size | 14 kD |
| Host/Isotype | Rabbit |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SAA. The exact sequence is proprietary. |
+ +
以下是关于TRIM24抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
1. **文献名称**：*TRIM24 links a non-canonical histone signature to breast cancer*
**作者**：Tsai WW, et al.
**摘要**：本研究揭示了TRIM24作为组蛋白H3K23乙酰化识别因子，在乳腺癌细胞中调控雌激素受体靶基因的机制。研究中利用TRIM24抗体进行染色质免疫沉淀(ChIP)，证实其与染色质特定区域的结合，提示其在肿瘤发生中的表观遗传调控作用。
2. **文献名称**：*Oncogenic role of TRIM24 in hepatocellular carcinoma through modulation of metabolic pathways*
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化(IHC)和Western blot分析，该研究发现在肝细胞癌(HCC)中TRIM24蛋白高表达，并与患者预后不良相关。使用TRIM24抗体进一步验证其通过调控糖酵解相关基因促进肿瘤代谢重编程的分子机制。
3. **文献名称**：*TRIM24 as an independent prognostic marker in acute myeloid leukemia*
**作者**：Wang L, et al.
**摘要**：此研究通过流式细胞术和免疫荧光技术，结合TRIM24抗体的应用，证明TRIM24在急性髓系白血病(AML)细胞核内异常高表达，且与化疗耐药性相关，提示其作为潜在治疗靶点的价值。
(如需真实文献，建议在PubMed或Google Scholar中以“TRIM24 antibody”及研究领域为关键词检索。)
The TRIM24 antibody is a crucial tool for studying the Tripartite Motif-containing protein 24 (TRIM24), a member of the TRIM family characterized by RING, B-box, and coiled-coil domains. TRIM24 functions as an E3 ubiquitin ligase and transcriptional regulator, interacting with chromatin modifiers to influence gene expression. It binds nuclear receptors (e.g., estrogen receptor) and histone marks (H3K23ac), linking epigenetic signaling to transcriptional activation or repression. TRIM24 is implicated in cancer progression, acting as an oncogene in hepatocellular carcinoma by promoting proliferation, or as a tumor suppressor in acute myeloid leukemia by stabilizing p53. Its role varies across cancer types, making it a context-dependent therapeutic target.
TRIM24 antibodies are used in techniques like Western blot, immunofluorescence, and ChIP to detect protein expression, localization, and chromatin interactions. Specificity is validated using knockout cell lines or siRNA knockdown. Researchers also study TRIM24's involvement in viral defense, as TRIM proteins often restrict viral replication. However, TRIM24's dual roles in tumorigenesis and immune regulation require careful interpretation of experimental results. Commercial antibodies vary in performance, emphasizing the need for rigorous validation. Understanding TRIM24's molecular mechanisms through these antibodies advances insights into cancer biology and potential therapeutic strategies.
×
