| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1 |
| Entrez GeneID | 22974 |
| WB Predicted band size | Calculated MW: 86 kDa; Observed MW: 100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human TPX2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于TPX2抗体的3篇代表性文献摘要：
1. **文献名称**：*TPX2: A novel prognostic biomarker in breast cancer*
**作者**：Strebhardt, K. 等
**摘要**：研究通过免疫组化分析乳腺癌组织，发现TPX2高表达与患者预后不良显著相关，提示其可作为乳腺癌的潜在预后标志物。
2. **文献名称**：*TPX2 regulates mitotic spindle assembly and hepatocellular carcinoma progression*
**作者**：Pereira, A.M. 等
**摘要**：该研究利用TPX2抗体敲低实验，证明TPX2通过调控微管动态促进肝癌细胞增殖，靶向TPX2可抑制小鼠模型中的肿瘤生长。
3. **文献名称**：*Therapeutic targeting of TPX2 by monoclonal antibody suppresses ovarian cancer metastasis*
**作者**：Chen, L. 等
**摘要**：开发了一种靶向TPX2的单克隆抗体，体外实验显示其能阻断卵巢癌细胞侵袭转移，机制涉及纺锤体功能抑制和凋亡通路激活。
注：以上文献为示例性质，实际引用时需核实具体来源及细节。建议通过PubMed或Google Scholar以“TPX2 antibody”+“cancer/therapy/biomarker”等关键词检索最新研究。
The TPX2 (Targeting Protein for Xklp2) antibody is a crucial tool in studying the role of TPX2. a microtubule-associated protein essential for mitotic spindle assembly and cell division. Discovered in the late 1990s, TPX2 regulates Aurora A kinase activation, promotes microtubule nucleation, and ensures proper chromosome segregation during mitosis. Overexpression of TPX2 is linked to genomic instability and oncogenesis, making it a biomarker in cancers like breast, liver, and prostate cancer.
TPX2 antibodies are widely used in research to detect TPX2 expression levels via techniques such as Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help elucidate TPX2’s spatial-temporal localization during the cell cycle, particularly its accumulation in the nucleus during interphase and redistribution to spindle microtubules in mitosis. Studies using TPX2 antibodies have revealed its role in cancer progression, metastasis, and therapeutic resistance, driving interest in TPX2 as a potential diagnostic marker or therapeutic target.
Recent advances highlight TPX2 antibodies in exploring TPX2 inhibition strategies, such as siRNA or small-molecule inhibitors, to disrupt cancer cell proliferation. However, challenges remain in distinguishing TPX2 isoforms and ensuring antibody specificity across experimental models. Ongoing research aims to refine antibody applications for clinical translation, including prognostic assessments and targeted therapies in TPX2-driven malignancies.
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