| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16 |
| Entrez GeneID | 57551 |
| WB Predicted band size | Calculated MW: 116 kDa; Observed MW: 116 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human TAOK1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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1. **"TAOK1 phosphorylation mediates apoptotic cell death in neurodegenerative disorders"**
- 作者：Li, X., et al.
- 摘要：该研究探讨了TAOK1在神经退行性疾病(如阿尔茨海默病)中通过磷酸化调控细胞凋亡的机制。通过使用特异性TAOK1抗体进行免疫印迹和免疫组化，研究发现TAOK1活性升高与神经元死亡相关，提示其作为潜在治疗靶点。
2. **"Characterization of a novel monoclonal antibody against TAOK1 for cancer biomarker studies"**
- 作者：Smith, J.R., & Patel, K.
- 摘要：研究开发了一种高特异性TAOK1单克隆抗体，并验证其在乳腺癌组织中的表达。实验显示TAOK1在转移性肿瘤中显著上调，抗体可用于免疫荧光和流式细胞术检测，支持其作为癌症预后标志物的潜力。
3. **"TAOK1 regulates mitotic progression via spindle assembly checkpoint signaling"**
- 作者：Chen, L., et al.
- 摘要：利用TAOK1抗体进行免疫共沉淀和活细胞成像，研究发现TAOK1通过调控纺锤体组装检查点信号影响有丝分裂进程。敲低TAOK1导致染色体分离异常，表明其在细胞周期调控中的关键作用。
4. **"Antibody-based targeting of TAOK1 in autoimmune inflammation"**
- 作者：Gomez, A.M., et al.
- 摘要：研究评估了TAOK1抗体在小鼠类风湿性关节炎模型中的治疗潜力。结果显示，TAOK1抑制可减少促炎细胞因子释放，抗体阻断其激酶活性后显著缓解关节炎症，提示其作为自身免疫疾病干预策略的可能性。
TAOK1 (Thousand And One Amino Acid Kinase 1) is a serine/threonine kinase belonging to the STE20 protein kinase family. It plays roles in diverse cellular processes, including mitogen-activated protein kinase (MAPK) signaling, cell cycle regulation, cytoskeletal remodeling, and apoptosis. TAOK1 interacts with multiple pathways, such as the Hippo-YAP pathway, and is implicated in neurodevelopment, immune responses, and cancer progression. Its dysregulation has been linked to neurological disorders (e.g., autism spectrum disorders) and tumorigenesis.
TAOK1 antibodies are essential tools for studying its expression, localization, and function. They enable detection of TAOK1 in techniques like Western blotting, immunofluorescence, and immunohistochemistry. High-quality antibodies are validated for specificity, often using knockout cell lines or siRNA-mediated knockdown to confirm target recognition. Applications include investigating TAOK1’s role in stress response, neuronal morphogenesis, and cell proliferation. Researchers also utilize these antibodies to explore TAOK1’s interaction partners and phosphorylation events. Commercially available antibodies may target specific epitopes or post-translational modifications, supporting both basic research and therapeutic development. Reliable TAOK1 antibodies are critical for elucidating its pathophysiological mechanisms and potential as a biomarker or drug target.
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