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Rabbit Monoclonal SuperoxideDismutase1 Antibody

  • 中文名： Superoxide Dismutase 1抗体
  • 别    名： SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
货号: IPDX22590
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
Entrez GeneID6647
WB Predicted band sizeCalculated MW: 16 kDa; Observed MW: 16 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human Superoxide Dismutase 1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3-4篇关于SOD1抗体的参考文献摘要概括：

1. **文献名称**: "Aggregation of mutant SOD1 in ALS mice is associated with motor neuron pathology"

**作者**: Turner BJ, et al.

**摘要**: 该研究利用SOD1特异性抗体检测转基因ALS小鼠模型中的SOD1蛋白聚集情况，揭示了突变体SOD1在运动神经元中的异常积累与疾病进展的相关性。

2. **文献名称**: "Therapeutic effect of SOD1-specific antibodies in ALS model mice"

**作者**: Urushitani M, et al.

**摘要**: 通过被动免疫疗法，研究团队验证了SOD1抗体对延缓ALS转基因小鼠疾病进展的效果，证明抗体可靶向胞外SOD1并减少神经元损伤。

3. **文献名称**: "Mislocalization of mutant SOD1 in spinal motor neurons correlates with mitochondrial dysfunction"

**作者**: Bosco DA, et al.

**摘要**: 使用SOD1抗体识别突变蛋白的亚细胞定位，发现突变体SOD1在线粒体的异常富集与运动神经元线粒体功能紊乱及氧化应激相关。

4. **文献名称**: "Antibody recognition of wild-type and mutant SOD1 in ALS patient tissues"

**作者**: Gao J, et al.

**摘要**: 通过多种SOD1抗体比较分析，揭示了不同抗体对病理状态下SOD1构象表位的识别差异，为ALS生物标志物研究提供实验依据。

(注：以上文献标题及作者为示例概括，实际文献需通过PubMed/Google Scholar按关键词检索确认。)

背景信息

Superoxide dismutase 1 (SOD1) is a ubiquitously expressed antioxidant enzyme that catalyzes the conversion of superoxide radicals into molecular oxygen and hydrogen peroxide, playing a critical role in cellular defense against oxidative stress. Mutations in the SOD1 gene are linked to approximately 20% of familial amyotrophic lateral sclerosis (ALS) cases, where misfolded mutant SOD1 proteins accumulate, leading to toxic gain-of-function effects such as protein aggregation, mitochondrial dysfunction, and neuronal apoptosis. SOD1 antibodies are essential tools for studying both wild-type and mutant SOD1 in research and diagnostics. These antibodies, typically generated in rabbits, mice, or goats, target specific epitopes within the SOD1 protein and are available as polyclonal or monoclonal forms. Polyclonal antibodies offer high sensitivity for detecting diverse SOD1 variants, while monoclonal antibodies provide specificity for consistent results in applications like Western blotting, immunohistochemistry, and ELISA. In ALS research, SOD1 antibodies help identify pathogenic aggregates, monitor disease progression, and validate therapeutic strategies targeting SOD1. such as antisense oligonucleotides. Commercial SOD1 antibodies often undergo validation in knockout models or ALS patient samples to ensure target specificity. However, variability in antibody performance across experimental conditions underscores the need for rigorous validation in specific assays. Overall, SOD1 antibodies remain pivotal in unraveling ALS mechanisms and advancing biomarker discovery.

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