| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AW496480; 1600010G07Rik |
| Entrez GeneID | 20847 |
| WB Predicted band size | Calculated MW: 105 kDa; Observed MW: 113 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of mouse STAT2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于STAT2抗体的参考文献示例(注：以下为虚构示例，仅供参考)：
1. **标题**: "STAT2 Signaling in Antiviral Immunity: Structural Insights and Functional Roles"
**作者**: Smith A, et al.
**摘要**: 该研究解析了STAT2蛋白在干扰素信号通路中的结构，揭示了其与IRF9形成复合物的关键区域，并利用特异性抗体验证了STAT2在抗病毒反应中的磷酸化调控机制。
2. **标题**: "Development of a High-Affinity Monoclonal Antibody for STAT2 Detection in Human Cells"
**作者**: Lee B, et al.
**摘要**: 文章报道了一种新型STAT2单克隆抗体的开发，该抗体在Western blot、免疫荧光中表现出高特异性，适用于研究STAT2在肿瘤细胞中的异常表达。
3. **标题**: "STAT2 Deficiency and Autoimmune Disorders: Insights from Knockout Mouse Models"
**作者**: Chen C, et al.
**摘要**: 通过STAT2基因敲除小鼠模型，研究发现STAT2缺失导致I型干扰素信号失调，并利用抗体染色证实了STAT2在免疫细胞中的定位异常与自身免疫疾病的关联。
4. **标题**: "STAT2 as a Therapeutic Target in Chronic Inflammatory Diseases"
**作者**: Gonzalez D, et al.
**摘要**: 综述了STAT2在炎症性疾病中的作用，总结了基于STAT2抗体的实验工具在药物筛选中的应用，并探讨了靶向STAT2的治疗策略潜力。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“STAT2 antibody”或“STAT2 function”，并筛选近年高影响力论文。
STAT2 (Signal Transducer and Activator of Transcription 2) is a critical transcription factor in the JAK-STAT signaling pathway, primarily activated by type I and III interferons (IFNs). It plays a central role in mediating innate immune responses against viral infections and regulating cell growth, differentiation, and apoptosis. Upon IFN stimulation, STAT2 is phosphorylated by receptor-associated JAK kinases, leading to its dimerization with STAT1 and formation of the IFN-stimulated gene factor 3 (ISGF3) complex alongside IRF9. This complex translocates to the nucleus to bind interferon-stimulated response elements (ISREs), driving the expression of interferon-stimulated genes (ISGs) with antiviral and immunomodulatory functions.
STAT2 antibodies are essential tools for studying its expression, activation, and interactions in immune signaling. They are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to assess STAT2 levels, phosphorylation status, and subcellular localization. Dysregulation of STAT2 has been implicated in immune disorders, viral evasion mechanisms, and cancers, making it a potential therapeutic target. For instance, STAT2 mutations or aberrant activation are linked to impaired antiviral responses, autoimmune diseases (e.g., lupus), and oncogenesis. Researchers also utilize STAT2 antibodies to explore cross-species differences, as STAT2’s role varies between humans and model organisms. Its therapeutic targeting, often in combination with JAK inhibitors, is being investigated for inflammatory diseases and cancer immunotherapy.
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