| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 100 kDa NT receptor; Glycoprotein 95; Gp95; LDLCQ6; Neurotensin receptor 3; NT3; NTR3; SORT 1; Sortilin 1 |
| Entrez GeneID | 6272 |
| WB Predicted band size | Calculated MW: 92 kDa; Observed MW: 92 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Recombinant protein of human Sortilin/NT3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Sortilin抗体的参考文献，简要概括如下：
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1. **标题**: *Sortilin-mediated apoptosis in neurodegenerative diseases*
**作者**: Carlo et al.
**摘要**: 研究探讨了Sortilin抗体在调节神经细胞凋亡中的作用，发现其通过抑制proNGF-Sortilin相互作用减轻阿尔茨海默病模型的神经元死亡。
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2. **标题**: *Antibody targeting of sortilin alters LDL metabolism and reduces atherosclerosis*
**作者**: Kjolby et al.
**摘要**: 开发了一种特异性Sortilin抗体，证明其能阻断Sortilin介导的脂蛋白摄取，显著降低动脉粥样硬化小鼠模型的斑块形成。
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3. **标题**: *A monoclonal antibody against sortilin suppresses breast cancer metastasis*
**作者**: Zhou et al.
**摘要**: 报道了一种单克隆Sortilin抗体，通过抑制肿瘤细胞Sortilin介导的VEGF释放，降低乳腺癌转移潜力，提示其治疗潜力。
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4. **标题**: *Sortilin antibodies reveal receptor trafficking dynamics in neurons*
**作者**: Evans et al.
**摘要**: 利用特异性Sortilin抗体追踪其在神经元内的运输途径，揭示其在突触可塑性和神经递质释放中的动态调节机制。
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这些文献覆盖了Sortilin抗体在疾病模型、代谢调控及基础机制研究中的应用。
Sortilin, encoded by the SORT1 gene, is a transmembrane receptor belonging to the Vps10p domain receptor family. It plays critical roles in intracellular protein sorting, neuronal survival, and receptor signaling. Sortilin mediates the trafficking of neurotrophic factors (e.g., proNGF, BDNF), regulates lipid metabolism by interacting with LDL receptors, and influences apoptosis through pathways involving progranulin and neurotensin. Dysregulation of sortilin is implicated in neurodegenerative diseases (e.g., Alzheimer’s, frontotemporal dementia), cardiovascular disorders, and metabolic syndromes.
Sortilin antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to quantify sortilin levels in tissues or cell lines, assess its subcellular distribution, and map binding domains. Specific antibodies targeting extracellular or intracellular epitopes help dissect sortilin’s dual roles in ligand internalization and signal transduction. In therapeutic research, anti-sortilin antibodies are explored for modulating sortilin-mediated pathways, such as blocking pro-apoptotic signals or enhancing neurotrophic support. Recent studies also highlight their potential in targeting sortilin for drug delivery or as biomarkers in diseases like atherosclerosis and cancer.
Overall, sortilin antibodies bridge basic research and clinical applications, offering insights into disease mechanisms and therapeutic strategies.
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