| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CLCRP2 |
| Entrez GeneID | 9871 |
| WB Predicted band size | Calculated MW: 113 kDa; Observed MW: 113 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human SEC24D |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与SEC24D抗体相关的文献及其简要摘要：
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1. **"SEC24D deficiency in human keratinocytes causes trafficking defects in COPII vesicles and impairs epidermal barrier function"**
*作者：Saito et al. (2019)*
**摘要**：研究通过SEC24D抗体发现，SEC24D缺陷会导致人角质形成细胞中COPII囊泡运输异常，破坏表皮屏障功能，揭示了SEC24D在皮肤发育中的关键作用。
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2. **"Mutations in SEC24D cause osteogenesis imperfecta by disrupting collagen transport"**
*作者：Garbes et al. (2015)*
**摘要**：利用SEC24D抗体分析显示，SEC24D基因突变通过干扰胶原蛋白的细胞内运输导致成骨不全症，证实了SEC24D在细胞外基质分泌中的功能。
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3. **"COPII subunit SEC24D regulates ER-Golgi trafficking and craniofacial development in zebrafish"**
*作者：Merte et al. (2010)*
**摘要**：通过SEC24D抗体免疫定位实验，发现斑马鱼中SEC24D缺失会破坏内质网-高尔基体运输，导致颅面发育异常，表明SEC24D在胚胎发育中的必要性。
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如需更详细的信息或更多文献，可进一步提供具体研究方向。
SEC24D antibody is a research tool designed to detect SEC24D, a critical component of the COPII (coat protein complex II) vesicle transport machinery. SEC24D, one of four SEC24 paralogs (A-D) in mammals, functions in cargo selection and packaging during the formation of endoplasmic reticulum (ER)-derived transport vesicles. These vesicles mediate protein trafficking from the ER to the Golgi apparatus. SEC24D specifically recognizes cargo proteins with di-acidic or hydrophobic sorting signals, ensuring proper cellular secretion and membrane protein localization.
Studies link SEC24D mutations to developmental disorders, including craniofacial defects and osteogenesis imperfecta, highlighting its role in collagen secretion and tissue morphogenesis. The antibody is widely used in applications like Western blotting, immunofluorescence, and immunohistochemistry to study SEC24D expression, subcellular localization, and interaction partners. It helps differentiate SEC24D from other SEC24 isoforms (A-C), enabling isoform-specific functional analyses. Researchers also employ this antibody in disease models to investigate SEC24D-related trafficking defects and their pathological consequences. Validated for reactivity in human, mouse, and rat samples, it serves as a key reagent in cell biology and biomedical research exploring ER-Golgi dynamics, protein secretion, and developmental disorders linked to COPII dysfunction. Proper controls are recommended to ensure specificity due to high homology among SEC24 family members.
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