| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADXR; ANOA |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FDXR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SBDS抗体的3篇模拟参考文献示例(文献信息为假设性描述，仅供格式参考)：
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1. **文献名称**：*SBDS Protein Function and Antibody Localization in Ribosome Biogenesis*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫荧光和Western blot技术，利用特异性SBDS抗体揭示了SBDS蛋白在哺乳动物细胞核仁中的定位，证实其参与核糖体RNA加工过程，为Shwachman-Diamond综合征的分子机制提供依据。
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2. **文献名称**：*Development of a Monoclonal SBDS Antibody for Clinical Diagnosis*
**作者**：Chen L, et al.
**摘要**：报道一种高灵敏度的单克隆SBDS抗体的开发，该抗体通过ELISA和免疫组化验证，可有效区分患者与健康个体的骨髓样本中SBDS蛋白表达水平，助力SDS的快速诊断。
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3. **文献名称**：*SBDS Interactions with EFL1 Revealed by Co-Immunoprecipitation*
**作者**：Garcia R, et al.
**摘要**：通过免疫共沉淀(使用SBDS多克隆抗体)和质谱分析，发现SBDS蛋白与EFL1形成复合物并调控核糖体成熟，突变实验中SBDS功能缺失导致60S亚基组装异常。
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(注：以上文献为模拟创作，实际引用请核实真实数据库如PubMed。)
Shwachman-Bodian-Diamond syndrome (SBDS) antibodies are primarily associated with research and diagnostic investigations of SBDS, a rare genetic disorder caused by mutations in the SBDS gene. This gene encodes the SBDS protein, which plays critical roles in ribosome biogenesis, RNA processing, and mitotic spindle stabilization. SBDS dysfunction leads to bone marrow failure, exocrine pancreatic insufficiency, and skeletal abnormalities.
Antibodies targeting the SBDS protein are essential tools for studying its expression, localization, and interactions in cellular models. They help elucidate molecular mechanisms underlying SBDS pathology, such as impaired ribosomal RNA maturation and disrupted hematopoiesis. Additionally, these antibodies aid in diagnosing SBDS by detecting protein expression deficits in patient-derived cells, complementing genetic testing.
Research using SBDS antibodies has highlighted the protein’s role in maintaining genomic stability and cellular stress responses, linking it to broader contexts like cancer and aging. However, challenges remain in standardizing antibody specificity due to the protein’s low abundance and structural complexity. Ongoing studies aim to refine antibody-based assays for therapeutic development, including strategies to restore SBDS function or target downstream pathways. Overall, SBDS antibodies are pivotal in advancing both basic science and clinical understanding of this multisystem disorder.
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