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Rabbit Monoclonal SARA Antibody

  • 中文名: SARA抗体
  • 别    名: NSP; SARA; MADHIP; SMADIP; PPP1R173
货号: IPDX22569
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNSP; SARA; MADHIP; SMADIP; PPP1R173
Entrez GeneID9372
WB Predicted band sizeCalculated MW: 156 kDa; Observed MW: 156 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human SARA
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于SARA(Smad Anchor for Receptor Activation)抗体的参考文献示例(注:以下内容为示例,非真实文献):

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1. **文献名称**:*SARA regulates TGF-β signaling by recruiting Smads to the activated receptor complex*

**作者**:Tsukazaki T, et al.

**摘要**:研究揭示了SARA蛋白在TGF-β信号通路中的作用,通过其FYVE结构域结合内体膜,介导Smad2/3与激活的TGF-β受体结合,促进信号转导。文中使用SARA抗体验证了其在受体复合体中的定位。

2. **文献名称**:*The role of SARA in fibrosis: Insights from antibody-based functional studies*

**作者**:Xi Q, et al.

**摘要**:通过特异性SARA抗体阻断实验,发现SARA在肝纤维化中调控TGF-β诱导的胶原沉积,表明其作为潜在治疗靶点的价值。

3. **文献名称**:*SARA-dependent endosomal trafficking in cancer metastasis*

**作者**:Di Guglielmo GM, Wrana JL

**摘要**:探讨SARA通过内体运输调控TGF-β信号的空间特异性,并利用SARA抗体证明其在乳腺癌细胞迁移中的关键作用。

4. **文献名称**:*Antibody profiling of SARA isoforms in developmental biology*

**作者**:Liu F, et al.

**摘要**:开发了针对不同SARA异构体的特异性抗体,发现其在胚胎发育过程中时空表达差异,提示其功能多样性。

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**注**:以上文献为示例,实际引用时需根据具体研究领域核实真实文献。如需真实文献,建议通过PubMed或Google Scholar搜索关键词“SARA antibody”或“Smad anchor for receptor activation”。

背景信息

SARA (Smad anchor for receptor activation) is a cytosolic scaffold protein critical for transforming growth factor-beta (TGF-β) signaling. It facilitates the activation of receptor-regulated Smads (R-Smads) by anchoring them to TGF-β receptor complexes. SARA contains a FYVE domain that directs its localization to early endosomes, where it recruits Smad2/3 to activated TGF-β receptors, enabling their phosphorylation and subsequent signaling. This process regulates diverse cellular responses, including proliferation, differentiation, and apoptosis.

SARA-specific antibodies are essential tools for studying TGF-β pathway dynamics. They enable detection of SARA expression levels, subcellular distribution (particularly endosomal localization), and interactions with Smads or receptors in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Research using these antibodies has revealed SARA's role in development and diseases; reduced SARA expression correlates with cancer progression and fibrotic disorders, likely due to impaired Smad activation. Antibodies targeting specific domains (e.g., FYVE or Smad-binding regions) further dissect SARA's functional mechanisms. However, interpretation requires caution due to potential cross-reactivity with homologous proteins. Overall, SARA antibodies remain vital for investigating TGF-β signaling aberrations in pathophysiology and therapeutic targeting.

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